Investigation of some endogenous antimicrobial peptides in thalassemia
The aim of this work was a comparative study of the amount of antimicrobial peptides - human neutrophil peptides - defensins (HNP), hepcidin, bactericidal/permeability-increasing protein (BPI), and endotoxin in β-thalassemia. Blood samples of 135 patients with thalassemia were investigated. All pati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Thalassemia Reports |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/thal/article/view/7744 |
| _version_ | 1797966851768057856 |
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| author | Arif Mustafa Efendiyev Gulnara Ibrahim Azizova Arzu Ramiz Dadashova |
| author_facet | Arif Mustafa Efendiyev Gulnara Ibrahim Azizova Arzu Ramiz Dadashova |
| author_sort | Arif Mustafa Efendiyev |
| collection | DOAJ |
| description | The aim of this work was a comparative study of the amount of antimicrobial peptides - human neutrophil peptides - defensins (HNP), hepcidin, bactericidal/permeability-increasing protein (BPI), and endotoxin in β-thalassemia. Blood samples of 135 patients with thalassemia were investigated. All patients were divided into 3 groups. The first group included patients with heterozygous form (n=45). The second group consisted of patients with homozygous form before splenectomy (n=45). The third group included patients with homozygous form after splenectomy (n=45). The age of patients varied from 2 to 18 years. Biochemical [unconjugated and conjugated bilirubin, alkaline phosphatase, hemoglobin, ferritin, aspartate transaminase (AST), alanine transaminase (ALT), mean corpuscular volume (MCV)] and immune (IgA, IgM, IgG, phagocytic activity) parameters were defined. Obtained results suggest that increased levels of endogenous antimicrobial peptides are associated with the development of the infectious process and reflect the dynamics of changes in biochemical parameters and immune status. |
| first_indexed | 2024-04-11T02:21:54Z |
| format | Article |
| id | doaj.art-ba2cbc4f77cd45bd8d22f03483251b50 |
| institution | Directory Open Access Journal |
| issn | 2039-4357 2039-4365 |
| language | English |
| last_indexed | 2024-04-11T02:21:54Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Thalassemia Reports |
| spelling | doaj.art-ba2cbc4f77cd45bd8d22f03483251b502023-01-02T23:41:03ZengMDPI AGThalassemia Reports2039-43572039-43652018-12-018210.4081/thal.2018.7744Investigation of some endogenous antimicrobial peptides in thalassemiaArif Mustafa Efendiyev0Gulnara Ibrahim Azizova1Arzu Ramiz Dadashova2Research Laboratory of Biochemistry Department, Azerbaijan Medical University, BakuResearch Laboratory of Biochemistry Department, Azerbaijan Medical University, BakuResearch Laboratory of Biochemistry Department, Azerbaijan Medical University, BakuThe aim of this work was a comparative study of the amount of antimicrobial peptides - human neutrophil peptides - defensins (HNP), hepcidin, bactericidal/permeability-increasing protein (BPI), and endotoxin in β-thalassemia. Blood samples of 135 patients with thalassemia were investigated. All patients were divided into 3 groups. The first group included patients with heterozygous form (n=45). The second group consisted of patients with homozygous form before splenectomy (n=45). The third group included patients with homozygous form after splenectomy (n=45). The age of patients varied from 2 to 18 years. Biochemical [unconjugated and conjugated bilirubin, alkaline phosphatase, hemoglobin, ferritin, aspartate transaminase (AST), alanine transaminase (ALT), mean corpuscular volume (MCV)] and immune (IgA, IgM, IgG, phagocytic activity) parameters were defined. Obtained results suggest that increased levels of endogenous antimicrobial peptides are associated with the development of the infectious process and reflect the dynamics of changes in biochemical parameters and immune status.https://www.pagepressjournals.org/index.php/thal/article/view/7744DefensinhepcidinBPIendotoxinβ-thalassemia. |
| spellingShingle | Arif Mustafa Efendiyev Gulnara Ibrahim Azizova Arzu Ramiz Dadashova Investigation of some endogenous antimicrobial peptides in thalassemia Thalassemia Reports Defensin hepcidin BPI endotoxin β-thalassemia. |
| title | Investigation of some endogenous antimicrobial peptides in thalassemia |
| title_full | Investigation of some endogenous antimicrobial peptides in thalassemia |
| title_fullStr | Investigation of some endogenous antimicrobial peptides in thalassemia |
| title_full_unstemmed | Investigation of some endogenous antimicrobial peptides in thalassemia |
| title_short | Investigation of some endogenous antimicrobial peptides in thalassemia |
| title_sort | investigation of some endogenous antimicrobial peptides in thalassemia |
| topic | Defensin hepcidin BPI endotoxin β-thalassemia. |
| url | https://www.pagepressjournals.org/index.php/thal/article/view/7744 |
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