Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses

Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative motor neuron (MN) disease. The gene encoding superoxide dismutase 1 (SOD1) is a causative element of familial ALS. Animal ALS models involving SOD1 gene mutations are widely used to study the underlying mechanisms of disease and facilitate d...

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Bibliographic Details
Main Authors: Takehisa Isobe, Norie Tooi, Norio Nakatsuji, Kazuhiro Aiba
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Stem Cell Research
Subjects:
Amyotrophic lateral sclerosis
SOD1
Human embryonic stem cell
Motor neuron
Drug response
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506115001191

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