Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder
BackgroundRapid eye movement sleep behavior disorder (RBD) and minor hallucinations (MHs) are prevalent nonmotor symptoms in Parkinson’s disease (PD). The purpose of this study was to explore the association of MHs in PD patients with probable RBD (pRBD).MethodsThis cross-sectional study included 29...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1205439/full |
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| author | Yinyin Jiang Jun Zhu Yang Zhao Dongfeng Li Yaning Chen Yaxi Wang Xu Jiang Bo Shen Yang Pan Jun Yan Feng Han Feng Han Li Zhang Li Zhang |
| author_facet | Yinyin Jiang Jun Zhu Yang Zhao Dongfeng Li Yaning Chen Yaxi Wang Xu Jiang Bo Shen Yang Pan Jun Yan Feng Han Feng Han Li Zhang Li Zhang |
| author_sort | Yinyin Jiang |
| collection | DOAJ |
| description | BackgroundRapid eye movement sleep behavior disorder (RBD) and minor hallucinations (MHs) are prevalent nonmotor symptoms in Parkinson’s disease (PD). The purpose of this study was to explore the association of MHs in PD patients with probable RBD (pRBD).MethodsThis cross-sectional study included 291 patients diagnosed with PD. Patients who scored 6 or higher on the Rapid Eye Movement Behavior Disorder (RBD) Screening Questionnaire were defined as pRBD. A comprehensive evaluation was performed for all patients, including the collection of demographic information, clinical assessment, and MH features.ResultsAmong the 291 PD patients, 69 (23.7%) had pRBD. MHs were observed in 35 (50.7%) patients with pRBD, significantly higher than 29.7% in patients without RBD (p = 0.015). The main type of MHs in pRBD was presence hallucinations with variable content. Patients with pRBD and MHs tended to be older, had a longer disease duration, and were more likely to take levodopa or dopamine-receptor agonists. Besides, the pRBD with MHs group had higher scores on the Nonmotor Symptoms Questionnaire (NMS-Quest) and Hamilton Anxiety Scale (HAMA). Binary logistic regression analysis revealed that longer disease duration and higher NMS-Quest scores were associated with MHs in PD patients with pRBD.ConclusionA high prevalence of MHs was observed in PD patients with pRBD. The main type of MHs in pRBD was presence hallucinations. MHs in PD with RBD are mainly associated with disease duration and severity of nonmotor symptoms. These findings provide new insights into the interaction between MHs and RBD. |
| first_indexed | 2024-03-12T14:56:49Z |
| format | Article |
| id | doaj.art-ba2dd4781af2460d9d7e9cf736fcec8f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T14:56:49Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-ba2dd4781af2460d9d7e9cf736fcec8f2023-08-14T18:01:14ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-08-011710.3389/fnins.2023.12054391205439Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorderYinyin Jiang0Jun Zhu1Yang Zhao2Dongfeng Li3Yaning Chen4Yaxi Wang5Xu Jiang6Bo Shen7Yang Pan8Jun Yan9Feng Han10Feng Han11Li Zhang12Li Zhang13Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaSchool of Pharmacy, Nanjing Medical University, Nanjing, ChinaInstitute of Brain Science, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaDepartment of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaInstitute of Neuropsychiatric Diseases, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaBackgroundRapid eye movement sleep behavior disorder (RBD) and minor hallucinations (MHs) are prevalent nonmotor symptoms in Parkinson’s disease (PD). The purpose of this study was to explore the association of MHs in PD patients with probable RBD (pRBD).MethodsThis cross-sectional study included 291 patients diagnosed with PD. Patients who scored 6 or higher on the Rapid Eye Movement Behavior Disorder (RBD) Screening Questionnaire were defined as pRBD. A comprehensive evaluation was performed for all patients, including the collection of demographic information, clinical assessment, and MH features.ResultsAmong the 291 PD patients, 69 (23.7%) had pRBD. MHs were observed in 35 (50.7%) patients with pRBD, significantly higher than 29.7% in patients without RBD (p = 0.015). The main type of MHs in pRBD was presence hallucinations with variable content. Patients with pRBD and MHs tended to be older, had a longer disease duration, and were more likely to take levodopa or dopamine-receptor agonists. Besides, the pRBD with MHs group had higher scores on the Nonmotor Symptoms Questionnaire (NMS-Quest) and Hamilton Anxiety Scale (HAMA). Binary logistic regression analysis revealed that longer disease duration and higher NMS-Quest scores were associated with MHs in PD patients with pRBD.ConclusionA high prevalence of MHs was observed in PD patients with pRBD. The main type of MHs in pRBD was presence hallucinations. MHs in PD with RBD are mainly associated with disease duration and severity of nonmotor symptoms. These findings provide new insights into the interaction between MHs and RBD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1205439/fullParkinson’s diseaseREM sleep behavior disorderRBDSQminor hallucinationpresence hallucination |
| spellingShingle | Yinyin Jiang Jun Zhu Yang Zhao Dongfeng Li Yaning Chen Yaxi Wang Xu Jiang Bo Shen Yang Pan Jun Yan Feng Han Feng Han Li Zhang Li Zhang Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder Frontiers in Neuroscience Parkinson’s disease REM sleep behavior disorder RBDSQ minor hallucination presence hallucination |
| title | Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder |
| title_full | Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder |
| title_fullStr | Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder |
| title_full_unstemmed | Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder |
| title_short | Minor hallucinations in Parkinson’s disease with probable rapid eye movement sleep behavior disorder |
| title_sort | minor hallucinations in parkinson s disease with probable rapid eye movement sleep behavior disorder |
| topic | Parkinson’s disease REM sleep behavior disorder RBDSQ minor hallucination presence hallucination |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1205439/full |
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