Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam
Using essential oils to control vectors, intermediate hosts, and disease-causing microorganisms is a promising approach. The genus <i>Croton</i> in the family Euphorbiaceae is a large genus, with many species containing large amounts of essential oils, however, essential oil studies are...
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/5/2361 |
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| author | Ngoc Anh Luu-dam Canh Viet Cuong Le Prabodh Satyal Thi Mai Hoa Le Van Huong Bui Van Hoa Vo Gia Huy Ngo Thi Chinh Bui Huy Hung Nguyen William N. Setzer |
| author_facet | Ngoc Anh Luu-dam Canh Viet Cuong Le Prabodh Satyal Thi Mai Hoa Le Van Huong Bui Van Hoa Vo Gia Huy Ngo Thi Chinh Bui Huy Hung Nguyen William N. Setzer |
| author_sort | Ngoc Anh Luu-dam |
| collection | DOAJ |
| description | Using essential oils to control vectors, intermediate hosts, and disease-causing microorganisms is a promising approach. The genus <i>Croton</i> in the family Euphorbiaceae is a large genus, with many species containing large amounts of essential oils, however, essential oil studies are limited in terms of the number of <i>Croton</i> species investigated. In this work, the aerial parts of <i>C. hirtus</i> growing wild in Vietnam were collected and analyzed by gas chromatography/mass spectrometry (GC/MS). A total of 141 compounds were identified in <i>C. hirtus</i> essential oil, in which sesquiterpenoids dominated, comprising 95.4%, including the main components β-caryophyllene (32.8%), germacrene D (11.6%), β-elemene (9.1%), α-humulene (8.5%), and caryophyllene oxide (5.0%). The essential oil of <i>C. hirtus</i> showed very strong biological activities against the larvae of four mosquito species with 24 h LC<sub>50</sub> values in the range of 15.38–78.27 μg/mL, against <i>Physella acuta</i> adults with a 48 h LC<sub>50</sub> value of 10.09 μg/mL, and against ATCC microorganisms with MIC values in the range of 8–16 μg/mL. In order to provide a comparison with previous works, a literature survey on the chemical composition, mosquito larvicidal, molluscicidal, antiparasitic, and antimicrobial activities of essential oils of <i>Croton</i> species was conducted. Seventy-two references (seventy articles and one book) out of a total of two hundred and forty-four references related to the chemical composition and bioactivity of essential oils of <i>Croton</i> species were used for this paper. The essential oils of some <i>Croton</i> species were characterized by their phenylpropanoid compounds. The experimental results of this research and the survey of the literature showed that <i>Croton</i> essential oils have the potential to be used to control mosquito-borne and mollusk-borne diseases, as well as microbial infections. Research on unstudied <i>Croton</i> species is needed to search for species with high essential oil contents and excellent biological activities. |
| first_indexed | 2024-03-11T07:16:54Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:16:54Z |
| publishDate | 2023-03-01 |
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| spelling | doaj.art-ba2e14fc08c04b4fae0f2ec1eb7986c22023-11-17T08:15:36ZengMDPI AGMolecules1420-30492023-03-01285236110.3390/molecules28052361Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from VietnamNgoc Anh Luu-dam0Canh Viet Cuong Le1Prabodh Satyal2Thi Mai Hoa Le3Van Huong Bui4Van Hoa Vo5Gia Huy Ngo6Thi Chinh Bui7Huy Hung Nguyen8William N. Setzer9Vietnam National Museum of Nature, Vietnam Academy of Science and Technology (VAST), No. 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 100803, VietnamMientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology (VAST), 321 Huynh Thuc Khang, Hue 530000, Thua Thien Hue, VietnamAromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USAFaculty of Pharmacy, Vinh Medical University, 161 Nguyen Phong Sac, Vinh 461150, VietnamVietnam National Museum of Nature, Vietnam Academy of Science and Technology (VAST), No. 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 100803, VietnamDepartment of Pharmacy, Duy Tan University, 03 Quang Trung, Da Nang 550000, VietnamDepartment of Pharmacy, Duy Tan University, 03 Quang Trung, Da Nang 550000, VietnamFaculty of Biology, University of Education, Hue University, 34 Le Loi St., Hue 530000, VietnamDepartment of Pharmacy, Duy Tan University, 03 Quang Trung, Da Nang 550000, VietnamAromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USAUsing essential oils to control vectors, intermediate hosts, and disease-causing microorganisms is a promising approach. The genus <i>Croton</i> in the family Euphorbiaceae is a large genus, with many species containing large amounts of essential oils, however, essential oil studies are limited in terms of the number of <i>Croton</i> species investigated. In this work, the aerial parts of <i>C. hirtus</i> growing wild in Vietnam were collected and analyzed by gas chromatography/mass spectrometry (GC/MS). A total of 141 compounds were identified in <i>C. hirtus</i> essential oil, in which sesquiterpenoids dominated, comprising 95.4%, including the main components β-caryophyllene (32.8%), germacrene D (11.6%), β-elemene (9.1%), α-humulene (8.5%), and caryophyllene oxide (5.0%). The essential oil of <i>C. hirtus</i> showed very strong biological activities against the larvae of four mosquito species with 24 h LC<sub>50</sub> values in the range of 15.38–78.27 μg/mL, against <i>Physella acuta</i> adults with a 48 h LC<sub>50</sub> value of 10.09 μg/mL, and against ATCC microorganisms with MIC values in the range of 8–16 μg/mL. In order to provide a comparison with previous works, a literature survey on the chemical composition, mosquito larvicidal, molluscicidal, antiparasitic, and antimicrobial activities of essential oils of <i>Croton</i> species was conducted. Seventy-two references (seventy articles and one book) out of a total of two hundred and forty-four references related to the chemical composition and bioactivity of essential oils of <i>Croton</i> species were used for this paper. The essential oils of some <i>Croton</i> species were characterized by their phenylpropanoid compounds. The experimental results of this research and the survey of the literature showed that <i>Croton</i> essential oils have the potential to be used to control mosquito-borne and mollusk-borne diseases, as well as microbial infections. Research on unstudied <i>Croton</i> species is needed to search for species with high essential oil contents and excellent biological activities.https://www.mdpi.com/1420-3049/28/5/2361<i>Croton</i>antimicrobialantiparasiticlarvicidalmolluscicidal |
| spellingShingle | Ngoc Anh Luu-dam Canh Viet Cuong Le Prabodh Satyal Thi Mai Hoa Le Van Huong Bui Van Hoa Vo Gia Huy Ngo Thi Chinh Bui Huy Hung Nguyen William N. Setzer Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam Molecules <i>Croton</i> antimicrobial antiparasitic larvicidal molluscicidal |
| title | Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam |
| title_full | Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam |
| title_fullStr | Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam |
| title_full_unstemmed | Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam |
| title_short | Chemistry and Bioactivity of <i>Croton</i> Essential Oils: Literature Survey and <i>Croton hirtus</i> from Vietnam |
| title_sort | chemistry and bioactivity of i croton i essential oils literature survey and i croton hirtus i from vietnam |
| topic | <i>Croton</i> antimicrobial antiparasitic larvicidal molluscicidal |
| url | https://www.mdpi.com/1420-3049/28/5/2361 |
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