β-HB treatment reverses sorafenib resistance by shifting glycolysis–lactate metabolism in HCC

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor. Although sorafenib and regorafenib have been approved for first-line and second-line treatment, respectively, of patients with advanced HCC, long-term treatment often results in acquired resistance. Given that glycolysis-medi...

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Bibliographic Details
Main Authors: Fat-Moon Suk, Chien-Ying Wu, Cheng-Chieh Fang, Tzu-Lang Chen, Yi-Jen Liao
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010843