Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence.

Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence.

MBP-1 acts as a general transcriptional repressor. Overexpression of MBP-1 induces cell death in a number of cancer cells and regresses tumor growth. However, the function of endogenous MBP-1 in normal cell growth regulation remains unknown. To unravel the role of endogenous MBP-1, we knocked down M...

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Bibliographic Details
Main Authors:	Asish K Ghosh, Tatsuo Kanda, Robert Steele, Ratna B Ray
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2557062?pdf=render

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