Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time
Ribosomal biogenesis is known to require nuclear to cytoplasmic export, but the precise kinetics remain unclear. Here, the authors use super-resolution confocal microscopy and single molecule tracking to visualize export of single pre-60S particles through nuclear pore complexes.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26323-7 |
| _version_ | 1818693584147185664 |
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| author | Jan Andreas Ruland Annika Marie Krüger Kerstin Dörner Rohan Bhatia Sabine Wirths Daniel Poetes Ulrike Kutay Jan Peter Siebrasse Ulrich Kubitscheck |
| author_facet | Jan Andreas Ruland Annika Marie Krüger Kerstin Dörner Rohan Bhatia Sabine Wirths Daniel Poetes Ulrike Kutay Jan Peter Siebrasse Ulrich Kubitscheck |
| author_sort | Jan Andreas Ruland |
| collection | DOAJ |
| description | Ribosomal biogenesis is known to require nuclear to cytoplasmic export, but the precise kinetics remain unclear. Here, the authors use super-resolution confocal microscopy and single molecule tracking to visualize export of single pre-60S particles through nuclear pore complexes. |
| first_indexed | 2024-12-17T13:16:00Z |
| format | Article |
| id | doaj.art-ba2f6db173b94b63a9e30b213dd11cd1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T13:16:00Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ba2f6db173b94b63a9e30b213dd11cd12022-12-21T21:46:59ZengNature PortfolioNature Communications2041-17232021-10-0112111210.1038/s41467-021-26323-7Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real timeJan Andreas Ruland0Annika Marie Krüger1Kerstin Dörner2Rohan Bhatia3Sabine Wirths4Daniel Poetes5Ulrike Kutay6Jan Peter Siebrasse7Ulrich Kubitscheck8Institute of Physical and Theoretical Chemistry, University of BonnInstitute of Physical and Theoretical Chemistry, University of BonnInstitute of Biochemistry, ETH ZurichInstitute of Physical and Theoretical Chemistry, University of BonnInstitute of Physical and Theoretical Chemistry, University of BonnInstitute of Physical and Theoretical Chemistry, University of BonnInstitute of Biochemistry, ETH ZurichInstitute of Physical and Theoretical Chemistry, University of BonnInstitute of Physical and Theoretical Chemistry, University of BonnRibosomal biogenesis is known to require nuclear to cytoplasmic export, but the precise kinetics remain unclear. Here, the authors use super-resolution confocal microscopy and single molecule tracking to visualize export of single pre-60S particles through nuclear pore complexes.https://doi.org/10.1038/s41467-021-26323-7 |
| spellingShingle | Jan Andreas Ruland Annika Marie Krüger Kerstin Dörner Rohan Bhatia Sabine Wirths Daniel Poetes Ulrike Kutay Jan Peter Siebrasse Ulrich Kubitscheck Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time Nature Communications |
| title | Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time |
| title_full | Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time |
| title_fullStr | Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time |
| title_full_unstemmed | Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time |
| title_short | Nuclear export of the pre-60S ribosomal subunit through single nuclear pores observed in real time |
| title_sort | nuclear export of the pre 60s ribosomal subunit through single nuclear pores observed in real time |
| url | https://doi.org/10.1038/s41467-021-26323-7 |
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