Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment
Abstract We performed liquid chromatography tandem mass spectrometry analysis with the targeted metabolomic kit Biocrates MxP Quant 500, in human brain cortex (Brodmann area 9) and putamen, to reveal metabolic changes characteristic of Parkinson’s disease (PD) and PD-related cognitive decline. This...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-023-00531-y |
| _version_ | 1797429577319972864 |
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| author | Karel Kalecký Teodoro Bottiglieri |
| author_facet | Karel Kalecký Teodoro Bottiglieri |
| author_sort | Karel Kalecký |
| collection | DOAJ |
| description | Abstract We performed liquid chromatography tandem mass spectrometry analysis with the targeted metabolomic kit Biocrates MxP Quant 500, in human brain cortex (Brodmann area 9) and putamen, to reveal metabolic changes characteristic of Parkinson’s disease (PD) and PD-related cognitive decline. This case-control study involved 101 subjects (33 PD without dementia, 32 PD with dementia (cortex only), 36 controls). We found changes associated with PD, cognitive status, levodopa levels, and disease progression. The affected pathways include neurotransmitters, bile acids, homocysteine metabolism, amino acids, TCA cycle, polyamines, β-alanine metabolism, fatty acids, acylcarnitines, ceramides, phosphatidylcholines, and several microbiome-derived metabolites. Previously reported levodopa-related homocysteine accumulation in cortex still best explains the dementia status in PD, which can be modified by dietary supplementation. Further investigation is needed to reveal the exact mechanisms behind this pathological change. |
| first_indexed | 2024-03-09T09:15:09Z |
| format | Article |
| id | doaj.art-ba3251c62ddd41e7b5ad48671fe232ba |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T09:15:09Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-ba3251c62ddd41e7b5ad48671fe232ba2023-12-02T07:23:31ZengNature Portfolionpj Parkinson's Disease2373-80572023-06-019111610.1038/s41531-023-00531-yTargeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairmentKarel Kalecký0Teodoro Bottiglieri1Institute of Biomedical Studies, Baylor UniversityCenter of Metabolomics, Institute of Metabolic Disease, Baylor Scott & White Research InstituteAbstract We performed liquid chromatography tandem mass spectrometry analysis with the targeted metabolomic kit Biocrates MxP Quant 500, in human brain cortex (Brodmann area 9) and putamen, to reveal metabolic changes characteristic of Parkinson’s disease (PD) and PD-related cognitive decline. This case-control study involved 101 subjects (33 PD without dementia, 32 PD with dementia (cortex only), 36 controls). We found changes associated with PD, cognitive status, levodopa levels, and disease progression. The affected pathways include neurotransmitters, bile acids, homocysteine metabolism, amino acids, TCA cycle, polyamines, β-alanine metabolism, fatty acids, acylcarnitines, ceramides, phosphatidylcholines, and several microbiome-derived metabolites. Previously reported levodopa-related homocysteine accumulation in cortex still best explains the dementia status in PD, which can be modified by dietary supplementation. Further investigation is needed to reveal the exact mechanisms behind this pathological change.https://doi.org/10.1038/s41531-023-00531-y |
| spellingShingle | Karel Kalecký Teodoro Bottiglieri Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment npj Parkinson's Disease |
| title | Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment |
| title_full | Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment |
| title_fullStr | Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment |
| title_full_unstemmed | Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment |
| title_short | Targeted metabolomic analysis in Parkinson’s disease brain frontal cortex and putamen with relation to cognitive impairment |
| title_sort | targeted metabolomic analysis in parkinson s disease brain frontal cortex and putamen with relation to cognitive impairment |
| url | https://doi.org/10.1038/s41531-023-00531-y |
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