Synthetic Peptides as Protein Mimics
The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins, represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have prov...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00211/full |
| _version_ | 1818837760727842816 |
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| author | Andrea eGroß Chie eHashimoto Heinrich eSticht Jutta eEichler |
| author_facet | Andrea eGroß Chie eHashimoto Heinrich eSticht Jutta eEichler |
| author_sort | Andrea eGroß |
| collection | DOAJ |
| description | The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins, represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites, since such peptides can be generated as exact copies of protein fragments, as well as in diverse chemical modifications, which includes the incorporation of a large range of non-proteinogenic amino acids, as well as the modification of the peptide backbone. Apart from extending the chemical and structural diversity presented by peptides, such modifications also increase the proteolytic stability of the molecules, enhancing their utility for biological applications. This article reviews recent advances by this and other laboratories in the use of synthetic protein mimics to modulate protein function, as well as to provide building blocks for synthetic biology. |
| first_indexed | 2024-12-19T03:27:38Z |
| format | Article |
| id | doaj.art-ba32b2bffd1c494ca79292c228da9156 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-19T03:27:38Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-ba32b2bffd1c494ca79292c228da91562022-12-21T20:37:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852016-01-01310.3389/fbioe.2015.00211169024Synthetic Peptides as Protein MimicsAndrea eGroß0Chie eHashimoto1Heinrich eSticht2Jutta eEichler3University of Erlangen-NurnbergUniversity of Erlangen-NurnbergUniversity of Erlangen-NurnbergUniversity of Erlangen-NurnbergThe design and generation of molecules capable of mimicking the binding and/or functional sites of proteins, represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites, since such peptides can be generated as exact copies of protein fragments, as well as in diverse chemical modifications, which includes the incorporation of a large range of non-proteinogenic amino acids, as well as the modification of the peptide backbone. Apart from extending the chemical and structural diversity presented by peptides, such modifications also increase the proteolytic stability of the molecules, enhancing their utility for biological applications. This article reviews recent advances by this and other laboratories in the use of synthetic protein mimics to modulate protein function, as well as to provide building blocks for synthetic biology.http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00211/fullPeptidesBiomaterialsStructure-based designprotein mimicsprotein-protein interaction (PPI) |
| spellingShingle | Andrea eGroß Chie eHashimoto Heinrich eSticht Jutta eEichler Synthetic Peptides as Protein Mimics Frontiers in Bioengineering and Biotechnology Peptides Biomaterials Structure-based design protein mimics protein-protein interaction (PPI) |
| title | Synthetic Peptides as Protein Mimics |
| title_full | Synthetic Peptides as Protein Mimics |
| title_fullStr | Synthetic Peptides as Protein Mimics |
| title_full_unstemmed | Synthetic Peptides as Protein Mimics |
| title_short | Synthetic Peptides as Protein Mimics |
| title_sort | synthetic peptides as protein mimics |
| topic | Peptides Biomaterials Structure-based design protein mimics protein-protein interaction (PPI) |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00211/full |
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