High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity
Abstract 2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-re...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-06-01
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| Series: | npj Materials Degradation |
| Online Access: | https://doi.org/10.1038/s41529-023-00362-5 |
| _version_ | 1797789656466587648 |
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| author | Jingzhi Yang Yami Ran Luyao Huang Chenhao Ren Xiangping Hao Lingwei Ma Dawei Zhang |
| author_facet | Jingzhi Yang Yami Ran Luyao Huang Chenhao Ren Xiangping Hao Lingwei Ma Dawei Zhang |
| author_sort | Jingzhi Yang |
| collection | DOAJ |
| description | Abstract 2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-represented. Here, we report a high-throughput optimizing strategy that combines highly miniaturized hydrogel synthesis and screening to fine design zwitterion-based hydrogel coatings. Compared with the traditional one-by-one synthesis and characterization methods, the proposed high-throughput strategy accelerated the discovery of candidate materials with a high-efficiency and cost-effective approach. To tailor multiple parameters of coatings, 1575 unique coating combinations with continuous gradients were prepared only required 600 μL reactant. The mechanical stability and drug-loading capacity of the coating spots were sequentially evaluated via immersion swelling, flow, tape-peeling, and dye-retaining tests. This strategy could efficiently reveal the composition/structure-function relationships of the hydrogel coatings and also other materials, which is promising for the rapid screening and design of desired implantable device surfaces. |
| first_indexed | 2024-03-13T01:53:46Z |
| format | Article |
| id | doaj.art-ba335ca886c34ebfbe639a5b6fc073a9 |
| institution | Directory Open Access Journal |
| issn | 2397-2106 |
| language | English |
| last_indexed | 2024-03-13T01:53:46Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Materials Degradation |
| spelling | doaj.art-ba335ca886c34ebfbe639a5b6fc073a92023-07-02T11:22:06ZengNature Portfolionpj Materials Degradation2397-21062023-06-017111010.1038/s41529-023-00362-5High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacityJingzhi Yang0Yami Ran1Luyao Huang2Chenhao Ren3Xiangping Hao4Lingwei Ma5Dawei Zhang6Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology BeijingBeijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology BeijingState Key Laboratory of Advanced Power Transmission Technology, State Grid Smart Grid Research Institute Co., Ltd.Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology BeijingNational Materials Corrosion and Protection Data Center, University of Science and Technology BeijingBeijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology BeijingBeijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology BeijingAbstract 2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-represented. Here, we report a high-throughput optimizing strategy that combines highly miniaturized hydrogel synthesis and screening to fine design zwitterion-based hydrogel coatings. Compared with the traditional one-by-one synthesis and characterization methods, the proposed high-throughput strategy accelerated the discovery of candidate materials with a high-efficiency and cost-effective approach. To tailor multiple parameters of coatings, 1575 unique coating combinations with continuous gradients were prepared only required 600 μL reactant. The mechanical stability and drug-loading capacity of the coating spots were sequentially evaluated via immersion swelling, flow, tape-peeling, and dye-retaining tests. This strategy could efficiently reveal the composition/structure-function relationships of the hydrogel coatings and also other materials, which is promising for the rapid screening and design of desired implantable device surfaces.https://doi.org/10.1038/s41529-023-00362-5 |
| spellingShingle | Jingzhi Yang Yami Ran Luyao Huang Chenhao Ren Xiangping Hao Lingwei Ma Dawei Zhang High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity npj Materials Degradation |
| title | High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity |
| title_full | High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity |
| title_fullStr | High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity |
| title_full_unstemmed | High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity |
| title_short | High-throughput screening of zwitterion-based coatings towards improved mechanical stability and drug-loading capacity |
| title_sort | high throughput screening of zwitterion based coatings towards improved mechanical stability and drug loading capacity |
| url | https://doi.org/10.1038/s41529-023-00362-5 |
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