DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS
Goal of the study: to investigate the informativeness of tuberculous mycobacteria detection by various techniques and to analyze the intensity of bacillary excretion in tuberculosis patients depending on their HIV status.Materials and methods. 360 HIV patients were examined due to suspected tubercul...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2017-08-01
|
| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1018 |
| _version_ | 1797703474232688640 |
|---|---|
| author | V. N. Ziminа O. E. Mikovа T. A. Vаretskаya S. Yu. Degtyarevа V. I. Sergevnin |
| author_facet | V. N. Ziminа O. E. Mikovа T. A. Vаretskаya S. Yu. Degtyarevа V. I. Sergevnin |
| author_sort | V. N. Ziminа |
| collection | DOAJ |
| description | Goal of the study: to investigate the informativeness of tuberculous mycobacteria detection by various techniques and to analyze the intensity of bacillary excretion in tuberculosis patients depending on their HIV status.Materials and methods. 360 HIV patients were examined due to suspected tuberculosis. The diagnostic procedure included two consecutive sputum test for acid fast bacilli (AFB)/tuberculous mycobacteria by fluorescent microscopy, molecular genetic tests and culture on liquid and solid media. Tuberculosis was diagnosed in 178 (49.4%) patients. The comparison group included 354 tuberculosis patients with negative HIV status including 113 patients who underwent the same diagnostic procedure as those suffering from TB/HIV co-infection.Results of the study. AFB were more often detected by fluorescent microscopy in HIV negative tuberculosis patients compared to those with TB/HIV co-infection (32.8 and 24.2% respectively), and the sensitivity of the other testing methods did not differ. Scarce bacillary excretion was confidently more often registered in those suffering from TB/HIV co-infection and less frequently they had massive bacillary excretion detected by culture on solid media compared to HIV negative tuberculosis patients. The complete diagnostic procedure demonstrated better sensitivity in those with TB/HIV co-infection compared to tuberculosis patients with negative HIV status (87.1 and 71.2%). |
| first_indexed | 2024-03-12T05:05:59Z |
| format | Article |
| id | doaj.art-ba34628fc6ee45bcb1e3f7f185ebf2d0 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T05:05:59Z |
| publishDate | 2017-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-ba34628fc6ee45bcb1e3f7f185ebf2d02023-09-03T08:57:18ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-08-01957172310.21292/2075-1230-2017-95-7-17-231018DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUSV. N. Ziminа0O. E. Mikovа1T. A. Vаretskаya2S. Yu. Degtyarevа3V. I. Sergevnin4ФГАОУ ВО «Российский университет дружбы народов»ГКУЗ ПК «Пермский краевой центр по профилактике и борьбе со СПИД и инфекционными заболеваниями»ГКУЗ ПК «Пермский краевой центр по профилактике и борьбе со СПИД и инфекционными заболеваниями»ФГАОУ ВО «Российский университет дружбы народов»ГБОУ ВПО «Пермский государственный медицинский университет им. акад. Е. А. Вагнера»Goal of the study: to investigate the informativeness of tuberculous mycobacteria detection by various techniques and to analyze the intensity of bacillary excretion in tuberculosis patients depending on their HIV status.Materials and methods. 360 HIV patients were examined due to suspected tuberculosis. The diagnostic procedure included two consecutive sputum test for acid fast bacilli (AFB)/tuberculous mycobacteria by fluorescent microscopy, molecular genetic tests and culture on liquid and solid media. Tuberculosis was diagnosed in 178 (49.4%) patients. The comparison group included 354 tuberculosis patients with negative HIV status including 113 patients who underwent the same diagnostic procedure as those suffering from TB/HIV co-infection.Results of the study. AFB were more often detected by fluorescent microscopy in HIV negative tuberculosis patients compared to those with TB/HIV co-infection (32.8 and 24.2% respectively), and the sensitivity of the other testing methods did not differ. Scarce bacillary excretion was confidently more often registered in those suffering from TB/HIV co-infection and less frequently they had massive bacillary excretion detected by culture on solid media compared to HIV negative tuberculosis patients. The complete diagnostic procedure demonstrated better sensitivity in those with TB/HIV co-infection compared to tuberculosis patients with negative HIV status (87.1 and 71.2%).https://www.tibl-journal.com/jour/article/view/1018туберкулезкоинфекциявич-инфекциямассивность бактериовыделенияинформативность выявления мбт |
| spellingShingle | V. N. Ziminа O. E. Mikovа T. A. Vаretskаya S. Yu. Degtyarevа V. I. Sergevnin DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS Туберкулез и болезни лёгких туберкулез коинфекция вич-инфекция массивность бактериовыделения информативность выявления мбт |
| title | DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS |
| title_full | DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS |
| title_fullStr | DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS |
| title_full_unstemmed | DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS |
| title_short | DETECTION OF TUBERCULOUS MYCOBACTERIA IN SPUTUM AND INTENSITY OF BACILLARY EXCRETION IN TUBERCULOSIS PATIENTS WITH VARIOUS HIV STATUS |
| title_sort | detection of tuberculous mycobacteria in sputum and intensity of bacillary excretion in tuberculosis patients with various hiv status |
| topic | туберкулез коинфекция вич-инфекция массивность бактериовыделения информативность выявления мбт |
| url | https://www.tibl-journal.com/jour/article/view/1018 |
| work_keys_str_mv | AT vnzimina detectionoftuberculousmycobacteriainsputumandintensityofbacillaryexcretionintuberculosispatientswithvarioushivstatus AT oemikova detectionoftuberculousmycobacteriainsputumandintensityofbacillaryexcretionintuberculosispatientswithvarioushivstatus AT tavaretskaya detectionoftuberculousmycobacteriainsputumandintensityofbacillaryexcretionintuberculosispatientswithvarioushivstatus AT syudegtyareva detectionoftuberculousmycobacteriainsputumandintensityofbacillaryexcretionintuberculosispatientswithvarioushivstatus AT visergevnin detectionoftuberculousmycobacteriainsputumandintensityofbacillaryexcretionintuberculosispatientswithvarioushivstatus |