Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode
A sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE). Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-shaped irreversible peak at 1.05 V vs Ag/AgCl...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2016-06-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://periodicos.ufms.br/index.php/orbital/article/view/16791 |
| _version_ | 1797946800012787712 |
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| author | Igor Rebech Jessica Scremin César Ricardo Teixeira Tarley Elen Romão Sartori |
| author_facet | Igor Rebech Jessica Scremin César Ricardo Teixeira Tarley Elen Romão Sartori |
| author_sort | Igor Rebech |
| collection | DOAJ |
| description | A sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE). Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-shaped irreversible peak at 1.05 V vs Ag/AgCl (3.0 mol L–1 KCl) in Britton-Robinson buffer solution (pH 5.0). The use of this electrode has been found to influence the electrochemical determination by presenting a higher intensity of oxidation current for ticlopidine and also a lower detection limit. Using differential pulse voltammetric modality, the obtained analytical curve was linear for ticlopidine concentration ranging from 0.75 to 20 µmol L–1, with detection limit of 0.10 µmol L–1. The proposed method was successfully used to determination of ticlopidine in pharmaceuticals, with satisfying results. In order to indicate that the method is of potential application in biological fluids adequate recovery results were obtained for the determination of ticlopidine in synthetic urine sample.
DOI: http://dx.doi.org/10.17807/orbital.v8i3.831
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| first_indexed | 2024-04-10T21:17:49Z |
| format | Article |
| id | doaj.art-ba34fc7ea5d1490ba54a00472b855b98 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-04-10T21:17:49Z |
| publishDate | 2016-06-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-ba34fc7ea5d1490ba54a00472b855b982023-01-20T11:01:20ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282016-06-0183Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste ElectrodeIgor Rebech0Jessica Scremin1César Ricardo Teixeira Tarley2Elen Romão Sartori3Universidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaUniversidade Estadual de LondrinaA sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE). Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-shaped irreversible peak at 1.05 V vs Ag/AgCl (3.0 mol L–1 KCl) in Britton-Robinson buffer solution (pH 5.0). The use of this electrode has been found to influence the electrochemical determination by presenting a higher intensity of oxidation current for ticlopidine and also a lower detection limit. Using differential pulse voltammetric modality, the obtained analytical curve was linear for ticlopidine concentration ranging from 0.75 to 20 µmol L–1, with detection limit of 0.10 µmol L–1. The proposed method was successfully used to determination of ticlopidine in pharmaceuticals, with satisfying results. In order to indicate that the method is of potential application in biological fluids adequate recovery results were obtained for the determination of ticlopidine in synthetic urine sample. DOI: http://dx.doi.org/10.17807/orbital.v8i3.831 https://periodicos.ufms.br/index.php/orbital/article/view/16791ticlopidine determinationpaste electrodedifferential pulse voltammetryurine sample |
| spellingShingle | Igor Rebech Jessica Scremin César Ricardo Teixeira Tarley Elen Romão Sartori Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode Orbital: The Electronic Journal of Chemistry ticlopidine determination paste electrode differential pulse voltammetry urine sample |
| title | Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode |
| title_full | Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode |
| title_fullStr | Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode |
| title_full_unstemmed | Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode |
| title_short | Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode |
| title_sort | sensitive voltammetric determination of ticlopidine in pharmaceuticals employing a multi walled carbon nanotubes paste electrode |
| topic | ticlopidine determination paste electrode differential pulse voltammetry urine sample |
| url | https://periodicos.ufms.br/index.php/orbital/article/view/16791 |
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