A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions
Objective: Psoriasis is a chronic inflammatory autoimmune disease. The effectiveness of noscapine has been employed as a helpful treatment for various disorders and subjected to recent theoretical breakthroughs.Materials and Methods: Psoriasis-like lesions were induced by topical application of 5% i...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-07-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_21828_40dcf5d274edd4ca20d71591d701cfa4.pdf |
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| author | Fahimeh Nourbakhsh Seyed Hadi Mousavi Pouria Rahmanian-Devin Vafa Baradaran Rahimi Hassan Rakhshandeh Vahid Reza Askari |
| author_facet | Fahimeh Nourbakhsh Seyed Hadi Mousavi Pouria Rahmanian-Devin Vafa Baradaran Rahimi Hassan Rakhshandeh Vahid Reza Askari |
| author_sort | Fahimeh Nourbakhsh |
| collection | DOAJ |
| description | Objective: Psoriasis is a chronic inflammatory autoimmune disease. The effectiveness of noscapine has been employed as a helpful treatment for various disorders and subjected to recent theoretical breakthroughs.Materials and Methods: Psoriasis-like lesions were induced by topical application of 5% imiquimod (IMQ) (10 mg/cm2 of skin) in male Balb/c mice and then medicated with a single oral dose of methotrexate (MET) as a positive control or daily oral treatment of noscapine (5, 15 and 45 mg/kg). In this way, skin inflammation intensity, psoriatic itchiness, psoriasis area severity index (PASI) score, ear length, thickness, and organ weight were daily measured. At the end of the study, histological and immunohistochemical and enzyme-linked immunosorbent assays (ELISA, for pro-/anti-inflammatory factors) were performed in each ear.Results: IMQ caused psoriasis-like lesions. Noscapine markedly alleviated macroscopic parameters, namely ear thickness, ear length, skin inflammation, itching, and organ weight, as well as microscopic parameters including, pathology and Ki67 and p53, and tissue immunological mediators, such as tumour necrosis factor (TNF-α), interleukin (IL)-10, transforming growth factor (TGF-β), interferon-g (IFN-g), IL-6, IL-17, and IL-23p19 in the psoriatic skin in a concentration manner (p<0.05-<0.001).Conclusion: Therefore, noscapine with good pharmacological properties has considerable effects on psoriasis inflammation. |
| first_indexed | 2024-03-12T14:21:45Z |
| format | Article |
| id | doaj.art-ba378b58d13447de8a67591cfa08ca70 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-03-12T14:21:45Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-ba378b58d13447de8a67591cfa08ca702023-08-19T03:20:23ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-07-0113441242810.22038/ajp.2023.2182821828A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesionsFahimeh Nourbakhsh0Seyed Hadi Mousavi1Pouria Rahmanian-Devin2Vafa Baradaran Rahimi3Hassan Rakhshandeh4Vahid Reza Askari5Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMedical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, IranObjective: Psoriasis is a chronic inflammatory autoimmune disease. The effectiveness of noscapine has been employed as a helpful treatment for various disorders and subjected to recent theoretical breakthroughs.Materials and Methods: Psoriasis-like lesions were induced by topical application of 5% imiquimod (IMQ) (10 mg/cm2 of skin) in male Balb/c mice and then medicated with a single oral dose of methotrexate (MET) as a positive control or daily oral treatment of noscapine (5, 15 and 45 mg/kg). In this way, skin inflammation intensity, psoriatic itchiness, psoriasis area severity index (PASI) score, ear length, thickness, and organ weight were daily measured. At the end of the study, histological and immunohistochemical and enzyme-linked immunosorbent assays (ELISA, for pro-/anti-inflammatory factors) were performed in each ear.Results: IMQ caused psoriasis-like lesions. Noscapine markedly alleviated macroscopic parameters, namely ear thickness, ear length, skin inflammation, itching, and organ weight, as well as microscopic parameters including, pathology and Ki67 and p53, and tissue immunological mediators, such as tumour necrosis factor (TNF-α), interleukin (IL)-10, transforming growth factor (TGF-β), interferon-g (IFN-g), IL-6, IL-17, and IL-23p19 in the psoriatic skin in a concentration manner (p<0.05-<0.001).Conclusion: Therefore, noscapine with good pharmacological properties has considerable effects on psoriasis inflammation.https://ajp.mums.ac.ir/article_21828_40dcf5d274edd4ca20d71591d701cfa4.pdfpsoriasisimiquimodinflammationnoscapinemethotrexate |
| spellingShingle | Fahimeh Nourbakhsh Seyed Hadi Mousavi Pouria Rahmanian-Devin Vafa Baradaran Rahimi Hassan Rakhshandeh Vahid Reza Askari A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions Avicenna Journal of Phytomedicine psoriasis imiquimod inflammation noscapine methotrexate |
| title | A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions |
| title_full | A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions |
| title_fullStr | A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions |
| title_full_unstemmed | A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions |
| title_short | A promising impact of oral administration of noscapine against imiquimod-induced psoriasis-like skin lesions |
| title_sort | promising impact of oral administration of noscapine against imiquimod induced psoriasis like skin lesions |
| topic | psoriasis imiquimod inflammation noscapine methotrexate |
| url | https://ajp.mums.ac.ir/article_21828_40dcf5d274edd4ca20d71591d701cfa4.pdf |
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