Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery
Abstract Objective Transoral robotic surgery (TORS) has become an effective treatment for early‐stage oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to analyze the clinical safety and efficacy of TORS for human papilloma virus (HPV)‐positive and HPV‐negative OPSCC in China. Methods Patien...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.1005 |
| _version_ | 1797895929918914560 |
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| author | Hui Li Xing Zhang Wenkuan Chen Quan Zhang Qiuli Li Shuwei Chen Zhongyuan Yang Xuan Su Shida Yan Ankui Yang Ming Song |
| author_facet | Hui Li Xing Zhang Wenkuan Chen Quan Zhang Qiuli Li Shuwei Chen Zhongyuan Yang Xuan Su Shida Yan Ankui Yang Ming Song |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Abstract Objective Transoral robotic surgery (TORS) has become an effective treatment for early‐stage oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to analyze the clinical safety and efficacy of TORS for human papilloma virus (HPV)‐positive and HPV‐negative OPSCC in China. Methods Patients with OPSCC of pT1‐T2 stage who underwent TORS from March 2017 to December 2021 were analyzed. Results A total of 83 patients (HPV‐positive, n = 25; HPV‐negative, n = 58) were included. The median age of the patients was 57.0 years and 71 were men. The majority of primary tumor sites were palatine tonsils (52, 62.7%) and base of tongues (20, 24.1%). Three patients have a positive margin. A total of 12 (14.5%) patients received tracheotomies, the average duration of tracheostomy tube use was 9.4 days, and nasogastric tube was 14.5 days. No patient had a long‐term tracheotomy. The 3‐year overall survival (OS), disease‐free survival (DFS), and recurrence‐free survival (RFS) for all 83 patients were 89.5%, 80.1%, and 83.3%, respectively. The OS at 3 years between the HPV‐positive group and HPV‐negative group were 100% versus 84.3% (P = .07), while the DFS and RFS between two groups also showed no significant difference. Among multivariate cox regression analysis of all potential risk factors, smoking was the significant risk factors for disease recurrence (P < .05). Conclusion Transoral robotic surgery achieved encouraging oncologic outcomes and safety in T1‐T2 stage OPSCC treatment, regardless of HPV status. Level of Evidence 4 |
| first_indexed | 2024-04-10T07:34:39Z |
| format | Article |
| id | doaj.art-ba3854f8f7a249159e7a581138e2c66f |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-10T07:34:39Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-ba3854f8f7a249159e7a581138e2c66f2023-02-23T13:23:02ZengWileyLaryngoscope Investigative Otolaryngology2378-80382023-02-018110311210.1002/lio2.1005Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgeryHui Li0Xing Zhang1Wenkuan Chen2Quan Zhang3Qiuli Li4Shuwei Chen5Zhongyuan Yang6Xuan Su7Shida Yan8Ankui Yang9Ming Song10Collaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaCollaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center Guangzhou ChinaAbstract Objective Transoral robotic surgery (TORS) has become an effective treatment for early‐stage oropharyngeal squamous cell carcinomas (OPSCCs). We aimed to analyze the clinical safety and efficacy of TORS for human papilloma virus (HPV)‐positive and HPV‐negative OPSCC in China. Methods Patients with OPSCC of pT1‐T2 stage who underwent TORS from March 2017 to December 2021 were analyzed. Results A total of 83 patients (HPV‐positive, n = 25; HPV‐negative, n = 58) were included. The median age of the patients was 57.0 years and 71 were men. The majority of primary tumor sites were palatine tonsils (52, 62.7%) and base of tongues (20, 24.1%). Three patients have a positive margin. A total of 12 (14.5%) patients received tracheotomies, the average duration of tracheostomy tube use was 9.4 days, and nasogastric tube was 14.5 days. No patient had a long‐term tracheotomy. The 3‐year overall survival (OS), disease‐free survival (DFS), and recurrence‐free survival (RFS) for all 83 patients were 89.5%, 80.1%, and 83.3%, respectively. The OS at 3 years between the HPV‐positive group and HPV‐negative group were 100% versus 84.3% (P = .07), while the DFS and RFS between two groups also showed no significant difference. Among multivariate cox regression analysis of all potential risk factors, smoking was the significant risk factors for disease recurrence (P < .05). Conclusion Transoral robotic surgery achieved encouraging oncologic outcomes and safety in T1‐T2 stage OPSCC treatment, regardless of HPV status. Level of Evidence 4https://doi.org/10.1002/lio2.1005clinical outcomehead and neck cancerHPV statusoropharyngeal squamous cell carcinomastransoral robotic surgery |
| spellingShingle | Hui Li Xing Zhang Wenkuan Chen Quan Zhang Qiuli Li Shuwei Chen Zhongyuan Yang Xuan Su Shida Yan Ankui Yang Ming Song Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery Laryngoscope Investigative Otolaryngology clinical outcome head and neck cancer HPV status oropharyngeal squamous cell carcinomas transoral robotic surgery |
| title | Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| title_full | Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| title_fullStr | Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| title_full_unstemmed | Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| title_short | Analysis of T1‐T2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| title_sort | analysis of t1 t2 stage oropharyngeal squamous cell carcinoma treated with transoral robotic surgery |
| topic | clinical outcome head and neck cancer HPV status oropharyngeal squamous cell carcinomas transoral robotic surgery |
| url | https://doi.org/10.1002/lio2.1005 |
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