Phaeohyphomycosis in China
BackgroundDue to more attentions paid to melanized fungi over the past few decades and under the background of the global coronavirus disease 2019 pandemic (COVID-19) the fact that the virus itself and the immunosuppressive agents such as glucocorticoids can further increase the risk of infections o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.895329/full |
| _version_ | 1828333000267399168 |
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| author | Yun He Yun He Yun He Hai-lin Zheng Hai-lin Zheng Huan Mei Huan Mei Gui-xia Lv Gui-xia Lv Wei-da Liu Wei-da Liu Xiao-fang Li Xiao-fang Li |
| author_facet | Yun He Yun He Yun He Hai-lin Zheng Hai-lin Zheng Huan Mei Huan Mei Gui-xia Lv Gui-xia Lv Wei-da Liu Wei-da Liu Xiao-fang Li Xiao-fang Li |
| author_sort | Yun He |
| collection | DOAJ |
| description | BackgroundDue to more attentions paid to melanized fungi over the past few decades and under the background of the global coronavirus disease 2019 pandemic (COVID-19) the fact that the virus itself and the immunosuppressive agents such as glucocorticoids can further increase the risk of infections of deep mycoses, the number of patients with phaeohyphomycosis (PHM) has a substantial increase. Their spectrum is broad and the early diagnosis and treatments are extremely sticky. This study aims to more comprehensively understand the clinical features of phaeohyphomycosis in China over 35 years and to establish a more applicable systematical classification and severity grades of lesions to guide treatments and prognosis.MethodsWe reviewed 174 cases of proven phaeohyphomycosis reported in Chinese and English language literature from 1987 to 2021 and we also made the accurate classification definitions and detailed information about the epidemiology, species of clinical dematiaceous fungi, minimum inhibitory concentration values, clinical features, treatments, and prognosis.ResultsThe mortality of cerebral, disseminated and pulmonary phaeohyphomycosis are 55%, 36%, and 25%. Nearly 19% of patients had poor quality of life caused by the complications such as disability, disfigurements, and blindness. The overall misdiagnosis rate of phaeohyphomycosis was 74%. Moderate to severe rashes are accounting for 82% of subcutaneous phaeohyphomycosis. The areas of the head and face are mostly affected accounting for 16% of severe rashes. Nearly 30% of invasive infections of phaeohyphomycosis are triggered by recurrent lesions. Voriconazole, itraconazole, amphotericin B deoxycholate (AmB-DOC), and terbinafine were most commonly used but diagnosis and treatments of phaeohyphomycosis remain challenging in reality.ConclusionsOur classifications are likely to be more practical and easier to popularize, and there are still also plenty of characteristics in these non-specific lesions. There’re no significant variations in cure rates, or death rates between three grades of lesions. But patients with severe rashes have longer courses and lower effective rates. |
| first_indexed | 2024-04-13T21:13:32Z |
| format | Article |
| id | doaj.art-ba39dff5692446cd9ae7eebd4d2beef4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T21:13:32Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-ba39dff5692446cd9ae7eebd4d2beef42022-12-22T02:29:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.895329895329Phaeohyphomycosis in ChinaYun He0Yun He1Yun He2Hai-lin Zheng3Hai-lin Zheng4Huan Mei5Huan Mei6Gui-xia Lv7Gui-xia Lv8Wei-da Liu9Wei-da Liu10Xiao-fang Li11Xiao-fang Li12Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaSkin Disease Prevention and Treatment Institute of Yixing, Yixing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, ChinaInstitute of Dermatology, Chinese Academy of Medical Science, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, ChinaBackgroundDue to more attentions paid to melanized fungi over the past few decades and under the background of the global coronavirus disease 2019 pandemic (COVID-19) the fact that the virus itself and the immunosuppressive agents such as glucocorticoids can further increase the risk of infections of deep mycoses, the number of patients with phaeohyphomycosis (PHM) has a substantial increase. Their spectrum is broad and the early diagnosis and treatments are extremely sticky. This study aims to more comprehensively understand the clinical features of phaeohyphomycosis in China over 35 years and to establish a more applicable systematical classification and severity grades of lesions to guide treatments and prognosis.MethodsWe reviewed 174 cases of proven phaeohyphomycosis reported in Chinese and English language literature from 1987 to 2021 and we also made the accurate classification definitions and detailed information about the epidemiology, species of clinical dematiaceous fungi, minimum inhibitory concentration values, clinical features, treatments, and prognosis.ResultsThe mortality of cerebral, disseminated and pulmonary phaeohyphomycosis are 55%, 36%, and 25%. Nearly 19% of patients had poor quality of life caused by the complications such as disability, disfigurements, and blindness. The overall misdiagnosis rate of phaeohyphomycosis was 74%. Moderate to severe rashes are accounting for 82% of subcutaneous phaeohyphomycosis. The areas of the head and face are mostly affected accounting for 16% of severe rashes. Nearly 30% of invasive infections of phaeohyphomycosis are triggered by recurrent lesions. Voriconazole, itraconazole, amphotericin B deoxycholate (AmB-DOC), and terbinafine were most commonly used but diagnosis and treatments of phaeohyphomycosis remain challenging in reality.ConclusionsOur classifications are likely to be more practical and easier to popularize, and there are still also plenty of characteristics in these non-specific lesions. There’re no significant variations in cure rates, or death rates between three grades of lesions. But patients with severe rashes have longer courses and lower effective rates.https://www.frontiersin.org/articles/10.3389/fcimb.2022.895329/fullphaeohyphomycosismelanized fungiepidemiologyrisk factorsclinical featuresdiagnosis |
| spellingShingle | Yun He Yun He Yun He Hai-lin Zheng Hai-lin Zheng Huan Mei Huan Mei Gui-xia Lv Gui-xia Lv Wei-da Liu Wei-da Liu Xiao-fang Li Xiao-fang Li Phaeohyphomycosis in China Frontiers in Cellular and Infection Microbiology phaeohyphomycosis melanized fungi epidemiology risk factors clinical features diagnosis |
| title | Phaeohyphomycosis in China |
| title_full | Phaeohyphomycosis in China |
| title_fullStr | Phaeohyphomycosis in China |
| title_full_unstemmed | Phaeohyphomycosis in China |
| title_short | Phaeohyphomycosis in China |
| title_sort | phaeohyphomycosis in china |
| topic | phaeohyphomycosis melanized fungi epidemiology risk factors clinical features diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.895329/full |
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