Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice
Coptis chinensis inflorescence is rich in isoquinoline alkaloids, especially berberine; these alkaloids comprise a chemical group with anti-hyperglycaemic effect. This study mainly investigated the α-amylase and α-glucosidase inhibitory activities of C. chinensis inflorescence extract (CE). The effe...
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Elsevier
2016-03-01
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Series: | Journal of Functional Foods |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464615006258 |
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author | Bingxin Ma Jing Tong Gao Zhou Qigui Mo Jingsheng He Youwei Wang |
author_facet | Bingxin Ma Jing Tong Gao Zhou Qigui Mo Jingsheng He Youwei Wang |
author_sort | Bingxin Ma |
collection | DOAJ |
description | Coptis chinensis inflorescence is rich in isoquinoline alkaloids, especially berberine; these alkaloids comprise a chemical group with anti-hyperglycaemic effect. This study mainly investigated the α-amylase and α-glucosidase inhibitory activities of C. chinensis inflorescence extract (CE). The effect of CE was similar to that of acarbose. Results of 3T3-L1 preadipocyte assay showed that CE can increase glucose consumption. In addition, CE and its main alkaloids (jatrorrhizine, columbamine, epiberberine, coptisine, palmatine, and berberine) were used to ameliorate streptozotocin-induced diabetic mice. Anti-hyperglycaemic activity was realised by reducing the blood glucose level and increasing the insulin content. Furthermore, CE and its main alkaloids can relieve liver injury and lipid metabolic disturbance. Therefore, CE exerts anti-hyperglycaemic activity, and alkaloids may be an active compound group. Overall, the results provide scientific foundation for C. chinensis inflorescence as functional food to ameliorate hyperglycaemia. |
first_indexed | 2024-12-17T01:09:14Z |
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issn | 1756-4646 |
language | English |
last_indexed | 2024-12-17T01:09:14Z |
publishDate | 2016-03-01 |
publisher | Elsevier |
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series | Journal of Functional Foods |
spelling | doaj.art-ba3a234b874d419293159298eb4f10902022-12-21T22:09:11ZengElsevierJournal of Functional Foods1756-46462016-03-0121455462Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic miceBingxin Ma0Jing Tong1Gao Zhou2Qigui Mo3Jingsheng He4Youwei Wang5Institute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaInstitute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaInstitute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaInstitute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaInstitute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, ChinaInstitute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), Wuhan University, Wuhan 430072, China; Corresponding author. Institute of TCM & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. Tel.: +86 027 68759323; fax: +86 027 68759010.Coptis chinensis inflorescence is rich in isoquinoline alkaloids, especially berberine; these alkaloids comprise a chemical group with anti-hyperglycaemic effect. This study mainly investigated the α-amylase and α-glucosidase inhibitory activities of C. chinensis inflorescence extract (CE). The effect of CE was similar to that of acarbose. Results of 3T3-L1 preadipocyte assay showed that CE can increase glucose consumption. In addition, CE and its main alkaloids (jatrorrhizine, columbamine, epiberberine, coptisine, palmatine, and berberine) were used to ameliorate streptozotocin-induced diabetic mice. Anti-hyperglycaemic activity was realised by reducing the blood glucose level and increasing the insulin content. Furthermore, CE and its main alkaloids can relieve liver injury and lipid metabolic disturbance. Therefore, CE exerts anti-hyperglycaemic activity, and alkaloids may be an active compound group. Overall, the results provide scientific foundation for C. chinensis inflorescence as functional food to ameliorate hyperglycaemia.http://www.sciencedirect.com/science/article/pii/S1756464615006258Coptis chinensis inflorescenceα-Glucosidaseα-Amylase3T3-L1StreptozotocinDiabetic |
spellingShingle | Bingxin Ma Jing Tong Gao Zhou Qigui Mo Jingsheng He Youwei Wang Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice Journal of Functional Foods Coptis chinensis inflorescence α-Glucosidase α-Amylase 3T3-L1 Streptozotocin Diabetic |
title | Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice |
title_full | Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice |
title_fullStr | Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice |
title_full_unstemmed | Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice |
title_short | Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice |
title_sort | coptis chinensis inflorescence ameliorates hyperglycaemia in 3t3 l1 preadipocyte and streptozotocin induced diabetic mice |
topic | Coptis chinensis inflorescence α-Glucosidase α-Amylase 3T3-L1 Streptozotocin Diabetic |
url | http://www.sciencedirect.com/science/article/pii/S1756464615006258 |
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