Strontium ranelate retards disc degradation and improves endplate and bone micro-architecture in ovariectomized rats with lumbar fusion induced – Adjacent segment disc degeneration

Strontium ranelate retards disc degradation and improves endplate and bone micro-architecture in ovariectomized rats with lumbar fusion induced – Adjacent segment disc degeneration

Objectives: Adjacent segment disc degeneration (ASDD) is one of the long-term sequelae of spinal fusion, which is more susceptible with osteoporosis. As an anti-osteoporosis drug, strontium ranelate (SR) has been reported to not only regulate bone metabolism but also cartilage matrix formation. Howe...

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Bibliographic Details
Main Authors: Qi Sun, Fang Liu, Jiakang Fang, Qiangqiang Lian, Yunpeng Hu, Xinyu Nan, Fa-Ming Tian, Guochuan Zhang, Dianwen Qi, Liu Zhang, Jingwen Zhang, Yang Luo, Zuzhuo Zhang, Zhuang Zhou
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Bone Reports
Subjects:
Strontium Ranelate
Adjacent segment disc degeneration
Osteoporosis
Rat
Ovariectomy
Lumbar fusion
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187224000111

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