The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism
In recent years, researchers have become focused on the relationship between lipids and bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders, such as nonalcoholic fatty liver disease, atherosclerosis, obesity, and menopause, are associated with osteoporotic phenotyp...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223004051 |
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| author | Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong |
| author_facet | Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | In recent years, researchers have become focused on the relationship between lipids and bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders, such as nonalcoholic fatty liver disease, atherosclerosis, obesity, and menopause, are associated with osteoporotic phenotypes. It has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone mass. Furthermore, similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal models. Abnormal lipid metabolism (such as increased oxidized lipids and elevated plasma cholesterol) affects bone microenvironment homeostasis via cross-organ communication, promoting differentiation of mesenchymal stem cells to adipocytes, and inhibiting commitment towards osteoblasts. Moreover, disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cytokines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of osteoclasts. Conclusively, this review addresses the possible link between lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism balance. We also summarize the possible approaches and prospects of intervening lipid metabolism for osteoporosis treatment. |
| first_indexed | 2024-04-24T22:41:53Z |
| format | Article |
| id | doaj.art-ba3b93e63b6c4e988afe80aae2d0b947 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T01:50:55Z |
| publishDate | 2024-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-ba3b93e63b6c4e988afe80aae2d0b9472024-05-08T04:07:32ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-07-01114101122The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanismJing Zhang0Wenhui Hu1Zhi Zou2Yuheng Li3Fei Kang4Jianmei Li5Shiwu Dong6College of Bioengineering, Chongqing University, Chongqing 400044, China; Department of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, ChinaDepartment of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, ChinaCollege of Bioengineering, Chongqing University, Chongqing 400044, ChinaDepartment of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, ChinaDepartment of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, ChinaDepartment of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, China; Corresponding author. Department of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Gaotanyan Street No. 30, Chongqing 400038, China.Department of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400038, China; Corresponding author. Department of Biomedical Materials Science, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Gaotanyan Street No. 30, Chongqing 400038, China.In recent years, researchers have become focused on the relationship between lipids and bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders, such as nonalcoholic fatty liver disease, atherosclerosis, obesity, and menopause, are associated with osteoporotic phenotypes. It has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone mass. Furthermore, similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal models. Abnormal lipid metabolism (such as increased oxidized lipids and elevated plasma cholesterol) affects bone microenvironment homeostasis via cross-organ communication, promoting differentiation of mesenchymal stem cells to adipocytes, and inhibiting commitment towards osteoblasts. Moreover, disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cytokines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of osteoclasts. Conclusively, this review addresses the possible link between lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism balance. We also summarize the possible approaches and prospects of intervening lipid metabolism for osteoporosis treatment.http://www.sciencedirect.com/science/article/pii/S2352304223004051Bone homeostasisCross-organ communicationLipid metabolismOsteoclastOsteoporosis |
| spellingShingle | Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism Genes and Diseases Bone homeostasis Cross-organ communication Lipid metabolism Osteoclast Osteoporosis |
| title | The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism |
| title_full | The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism |
| title_fullStr | The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism |
| title_full_unstemmed | The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism |
| title_short | The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism |
| title_sort | role of lipid metabolism in osteoporosis clinical implication and cellular mechanism |
| topic | Bone homeostasis Cross-organ communication Lipid metabolism Osteoclast Osteoporosis |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223004051 |
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