Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer
Tumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.571516/full |
| _version_ | 1819228145043111936 |
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| author | Ping Zheng Wei Li |
| author_facet | Ping Zheng Wei Li |
| author_sort | Ping Zheng |
| collection | DOAJ |
| description | Tumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with plastic properties. This review will focus on the evolution of phenotypes and functions of either MSCs or TAMs, which is “educated” by the TME, as well as interactions between MSCs and TAMs contributing to the distinct stages of tumor biology in gastric cancer. MSCs exert immunoregulatory effects on macrophages and polarize them toward M2-like TAMs, via cell–cell contact and paracrine or extracellular vesicle (EV) transfer mechanism. In turn, M2-TAMs modulate the transition of “naive” MSCs into tumor-derived MSCs, which possess a more potent pro-tumor role than the parent. Moreover, the cross talk between MSCs and TAMs could contribute to cancer biology by inducing the EMT process, metastasis, immune invasion, and immunotherapy resistance in cancer cells. However, molecular mechanisms underlying interactions between MSCs and TAMs in gastric cancer progression need to be thoroughly elucidated, which may provide attractive targets for making promising novel strategies for gastric cancer therapy. |
| first_indexed | 2024-12-23T10:52:37Z |
| format | Article |
| id | doaj.art-ba3c573c46ce484f9a1ed96d8b5fed02 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T10:52:37Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ba3c573c46ce484f9a1ed96d8b5fed022022-12-21T17:49:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.571516571516Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric CancerPing Zheng0Wei Li1Department of Laboratory Medicine, The First People’s Hospital of Lianyungang, Lianyungang, ChinaCenter of Research Laboratory, The First People’s Hospital of Lianyungang, Lianyungang, ChinaTumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with plastic properties. This review will focus on the evolution of phenotypes and functions of either MSCs or TAMs, which is “educated” by the TME, as well as interactions between MSCs and TAMs contributing to the distinct stages of tumor biology in gastric cancer. MSCs exert immunoregulatory effects on macrophages and polarize them toward M2-like TAMs, via cell–cell contact and paracrine or extracellular vesicle (EV) transfer mechanism. In turn, M2-TAMs modulate the transition of “naive” MSCs into tumor-derived MSCs, which possess a more potent pro-tumor role than the parent. Moreover, the cross talk between MSCs and TAMs could contribute to cancer biology by inducing the EMT process, metastasis, immune invasion, and immunotherapy resistance in cancer cells. However, molecular mechanisms underlying interactions between MSCs and TAMs in gastric cancer progression need to be thoroughly elucidated, which may provide attractive targets for making promising novel strategies for gastric cancer therapy.https://www.frontiersin.org/article/10.3389/fonc.2020.571516/fullmesenchymal stromal cellstumor-associated macrophagesgastric cancertumor microenvironmentextracellular vesicles |
| spellingShingle | Ping Zheng Wei Li Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer Frontiers in Oncology mesenchymal stromal cells tumor-associated macrophages gastric cancer tumor microenvironment extracellular vesicles |
| title | Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer |
| title_full | Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer |
| title_fullStr | Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer |
| title_full_unstemmed | Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer |
| title_short | Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer |
| title_sort | crosstalk between mesenchymal stromal cells and tumor associated macrophages in gastric cancer |
| topic | mesenchymal stromal cells tumor-associated macrophages gastric cancer tumor microenvironment extracellular vesicles |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.571516/full |
| work_keys_str_mv | AT pingzheng crosstalkbetweenmesenchymalstromalcellsandtumorassociatedmacrophagesingastriccancer AT weili crosstalkbetweenmesenchymalstromalcellsandtumorassociatedmacrophagesingastriccancer |