Stroke-like Episodes in Inherited Neurometabolic Disorders
Stroke-like episodes (SLEs) are significant clinical manifestations of metabolic disorders affecting the central nervous system. Morphological equivalents presented in neuroimaging procedures are described as stroke-like lesions (SLLs). It is crucial to distinguish SLEs from cerebral infarction or i...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/10/929 |
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| author | Natalia Będkowska Aneta Zontek Justyna Paprocka |
| author_facet | Natalia Będkowska Aneta Zontek Justyna Paprocka |
| author_sort | Natalia Będkowska |
| collection | DOAJ |
| description | Stroke-like episodes (SLEs) are significant clinical manifestations of metabolic disorders affecting the central nervous system. Morphological equivalents presented in neuroimaging procedures are described as stroke-like lesions (SLLs). It is crucial to distinguish SLEs from cerebral infarction or intracerebral hemorrhage, mainly due to the variety in management. Another significant issue to underline is the meaning of the main pathogenetic hypotheses in the development of SLEs. The diagnostic process is based on the patient’s medical history, physical and neurological examination, neuroimaging techniques and laboratory and genetic testing. Implementation of treatment is generally symptomatic and includes L-arginine supplementation and adequate antiepileptic management. The main aim of the current review was to summarize the basic and actual knowledge about the occurrence of SLEs in various inherited neurometabolic disorders, discuss the possible pathomechanism of their development, underline the role of neuroimaging in the detection of SLLs and identification of the electroencephalographic patterns as well as histological abnormalities in inherited disorders of metabolism. |
| first_indexed | 2024-03-09T19:49:34Z |
| format | Article |
| id | doaj.art-ba3ce8eba60f43ecacc02d0b246c243b |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T19:49:34Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ba3ce8eba60f43ecacc02d0b246c243b2023-11-24T01:15:23ZengMDPI AGMetabolites2218-19892022-09-01121092910.3390/metabo12100929Stroke-like Episodes in Inherited Neurometabolic DisordersNatalia Będkowska0Aneta Zontek1Justyna Paprocka2Students’ Scientific Society, Department of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, PolandStudents’ Scientific Society, Department of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, PolandStroke-like episodes (SLEs) are significant clinical manifestations of metabolic disorders affecting the central nervous system. Morphological equivalents presented in neuroimaging procedures are described as stroke-like lesions (SLLs). It is crucial to distinguish SLEs from cerebral infarction or intracerebral hemorrhage, mainly due to the variety in management. Another significant issue to underline is the meaning of the main pathogenetic hypotheses in the development of SLEs. The diagnostic process is based on the patient’s medical history, physical and neurological examination, neuroimaging techniques and laboratory and genetic testing. Implementation of treatment is generally symptomatic and includes L-arginine supplementation and adequate antiepileptic management. The main aim of the current review was to summarize the basic and actual knowledge about the occurrence of SLEs in various inherited neurometabolic disorders, discuss the possible pathomechanism of their development, underline the role of neuroimaging in the detection of SLLs and identification of the electroencephalographic patterns as well as histological abnormalities in inherited disorders of metabolism.https://www.mdpi.com/2218-1989/12/10/929stroke-like episodestroke-like lesioninherited errors of metabolismneurometabolic disordersMELASMERRF |
| spellingShingle | Natalia Będkowska Aneta Zontek Justyna Paprocka Stroke-like Episodes in Inherited Neurometabolic Disorders Metabolites stroke-like episode stroke-like lesion inherited errors of metabolism neurometabolic disorders MELAS MERRF |
| title | Stroke-like Episodes in Inherited Neurometabolic Disorders |
| title_full | Stroke-like Episodes in Inherited Neurometabolic Disorders |
| title_fullStr | Stroke-like Episodes in Inherited Neurometabolic Disorders |
| title_full_unstemmed | Stroke-like Episodes in Inherited Neurometabolic Disorders |
| title_short | Stroke-like Episodes in Inherited Neurometabolic Disorders |
| title_sort | stroke like episodes in inherited neurometabolic disorders |
| topic | stroke-like episode stroke-like lesion inherited errors of metabolism neurometabolic disorders MELAS MERRF |
| url | https://www.mdpi.com/2218-1989/12/10/929 |
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