The ethical case for placebo control in HIV-cure-related studies with ART interruption
Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S205566402200022X |
| _version_ | 1798019920517136384 |
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| author | Monica Magalhaes Daniel R. Kuritzkes Nir Eyal |
| author_facet | Monica Magalhaes Daniel R. Kuritzkes Nir Eyal |
| author_sort | Monica Magalhaes |
| collection | DOAJ |
| description | Many studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined. |
| first_indexed | 2024-04-11T16:49:14Z |
| format | Article |
| id | doaj.art-ba3d0be3fc9d4a0db364f45b13a41458 |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-04-11T16:49:14Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-ba3d0be3fc9d4a0db364f45b13a414582022-12-22T04:13:30ZengElsevierJournal of Virus Eradication2055-66402022-09-0183100084The ethical case for placebo control in HIV-cure-related studies with ART interruptionMonica Magalhaes0Daniel R. Kuritzkes1Nir Eyal2Center for Population-Level Bioethics, Rutgers University, New Brunswick, NJ, USA; Corresponding author.Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USACenter for Population-Level Bioethics, Rutgers University, New Brunswick, NJ, USA; Department of Philosophy, Rutgers University, New Brunswick, NJ, USA; Department of Health Behavior, Society, and Policy, Rutgers School of Public Health, Piscataway, NJ, USAMany studies that seek to cure HIV must ask participants to interrupt their antiretroviral treatment. In such circumstances, is it permissible to include a placebo group in the study? We explain why doing so is a scientific and an ethical necessity, and more benign than imagined.http://www.sciencedirect.com/science/article/pii/S205566402200022XHIV Cure-related studiesHuman subjects researchResearch ethicsAnalytic treatment interruptionPlacebos |
| spellingShingle | Monica Magalhaes Daniel R. Kuritzkes Nir Eyal The ethical case for placebo control in HIV-cure-related studies with ART interruption Journal of Virus Eradication HIV Cure-related studies Human subjects research Research ethics Analytic treatment interruption Placebos |
| title | The ethical case for placebo control in HIV-cure-related studies with ART interruption |
| title_full | The ethical case for placebo control in HIV-cure-related studies with ART interruption |
| title_fullStr | The ethical case for placebo control in HIV-cure-related studies with ART interruption |
| title_full_unstemmed | The ethical case for placebo control in HIV-cure-related studies with ART interruption |
| title_short | The ethical case for placebo control in HIV-cure-related studies with ART interruption |
| title_sort | ethical case for placebo control in hiv cure related studies with art interruption |
| topic | HIV Cure-related studies Human subjects research Research ethics Analytic treatment interruption Placebos |
| url | http://www.sciencedirect.com/science/article/pii/S205566402200022X |
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