Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study
The purposes of this study were to determine the incidence of hepatocellular carcinoma (HCC) in dual hepatitis B virus (HBV) and hepatitis C virus (HCV) endemic areas and to assess the associated risk factors of HCC development in the community. During April 2004 to November 2005, 4,127 residents of...
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| Format: | Article |
| Language: | English |
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Wiley
2011-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X1000032X |
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| author | Kuo-Chin Chang Sheng-Nan Lu Pao-Fei Chen Chao-Hung Hung Kwong-Ming Kee Yi-Hao Yen Jing-Houng Wang 張國欽 盧勝男 陳寶妃 洪肇宏 紀廣明 顏毅豪 王景弘 |
| author_facet | Kuo-Chin Chang Sheng-Nan Lu Pao-Fei Chen Chao-Hung Hung Kwong-Ming Kee Yi-Hao Yen Jing-Houng Wang 張國欽 盧勝男 陳寶妃 洪肇宏 紀廣明 顏毅豪 王景弘 |
| author_sort | Kuo-Chin Chang |
| collection | DOAJ |
| description | The purposes of this study were to determine the incidence of hepatocellular carcinoma (HCC) in dual hepatitis B virus (HBV) and hepatitis C virus (HCV) endemic areas and to assess the associated risk factors of HCC development in the community. During April 2004 to November 2005, 4,127 residents of Tainan County, aged 40 years or older, had participated in a comprehensive health examination. Among them, residents with HBV or HCV infection; platelet count less than or equal to 150×109/L; and no hepatic tumor, by liver ultrasonography, were invited to this study. Alpha-fetoprotein (AFP) screening and ultrasonography for HCC surveillance were performed. Once hepatic tumor was detected, the subjects were referred to medical centers for further confirmation and treatment. A total of 1,133 residents were eligible for this study, and 413 (36.5%), including 197 men and 216 women, with a mean age of 64.5 years, were enrolled. There were 21 cases with suspected HCC. Of the 21 cases, 18 (85.7%) accepted further studies and 11 (52.4%) were confirmed to be affected with HCC. All HCCs were unifocal with a diameter less than or equal to 4 cm. In the Kaplan–Meier survival analysis, the 2-year cumulative incidence of HCC was 4.7%. Based on the same analysis with log rank test, AFP greater than or equal to 20 ng/mL (p=0.007), platelet count less than or equal to 100×109/L (p<0.001), and liver cirrhosis (p<0.001) were found to be the associated risk factors of HCC development. In summary, the 2-year cumulative incidence of HCC was 4.7% among adult residents with chronic HBV or HCV infection in this dual HBV and HCV endemic area. Platelet count less than 100×109/L, AFP level greater than 20 ng/mL, and liver cirrhosis were the associated risk factors for HCC development. |
| first_indexed | 2024-12-12T10:03:29Z |
| format | Article |
| id | doaj.art-ba3e86ad88ac4c98845af06982af0df8 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-12T10:03:29Z |
| publishDate | 2011-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-ba3e86ad88ac4c98845af06982af0df82022-12-22T00:27:56ZengWileyKaohsiung Journal of Medical Sciences1607-551X2011-03-01273859010.1016/j.kjms.2010.11.001Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance studyKuo-Chin Chang0Sheng-Nan Lu1Pao-Fei Chen2Chao-Hung Hung3Kwong-Ming Kee4Yi-Hao Yen5Jing-Houng Wang6張國欽7盧勝男8陳寶妃9洪肇宏10紀廣明11顏毅豪12王景弘13Division of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, TaiwanThe purposes of this study were to determine the incidence of hepatocellular carcinoma (HCC) in dual hepatitis B virus (HBV) and hepatitis C virus (HCV) endemic areas and to assess the associated risk factors of HCC development in the community. During April 2004 to November 2005, 4,127 residents of Tainan County, aged 40 years or older, had participated in a comprehensive health examination. Among them, residents with HBV or HCV infection; platelet count less than or equal to 150×109/L; and no hepatic tumor, by liver ultrasonography, were invited to this study. Alpha-fetoprotein (AFP) screening and ultrasonography for HCC surveillance were performed. Once hepatic tumor was detected, the subjects were referred to medical centers for further confirmation and treatment. A total of 1,133 residents were eligible for this study, and 413 (36.5%), including 197 men and 216 women, with a mean age of 64.5 years, were enrolled. There were 21 cases with suspected HCC. Of the 21 cases, 18 (85.7%) accepted further studies and 11 (52.4%) were confirmed to be affected with HCC. All HCCs were unifocal with a diameter less than or equal to 4 cm. In the Kaplan–Meier survival analysis, the 2-year cumulative incidence of HCC was 4.7%. Based on the same analysis with log rank test, AFP greater than or equal to 20 ng/mL (p=0.007), platelet count less than or equal to 100×109/L (p<0.001), and liver cirrhosis (p<0.001) were found to be the associated risk factors of HCC development. In summary, the 2-year cumulative incidence of HCC was 4.7% among adult residents with chronic HBV or HCV infection in this dual HBV and HCV endemic area. Platelet count less than 100×109/L, AFP level greater than 20 ng/mL, and liver cirrhosis were the associated risk factors for HCC development.http://www.sciencedirect.com/science/article/pii/S1607551X1000032XHepatocellular carcinomaIncidenceSurveillanceThrombocytopeniaUltrasonography |
| spellingShingle | Kuo-Chin Chang Sheng-Nan Lu Pao-Fei Chen Chao-Hung Hung Kwong-Ming Kee Yi-Hao Yen Jing-Houng Wang 張國欽 盧勝男 陳寶妃 洪肇宏 紀廣明 顏毅豪 王景弘 Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study Kaohsiung Journal of Medical Sciences Hepatocellular carcinoma Incidence Surveillance Thrombocytopenia Ultrasonography |
| title | Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study |
| title_full | Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study |
| title_fullStr | Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study |
| title_full_unstemmed | Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study |
| title_short | Incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis B and C virus endemic area: A surveillance study |
| title_sort | incidence and associated risk factors of hepatocellular carcinoma in a dural hepatitis b and c virus endemic area a surveillance study |
| topic | Hepatocellular carcinoma Incidence Surveillance Thrombocytopenia Ultrasonography |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X1000032X |
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