Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model

Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model

Spina bifida aperta (SBA), one of the most common congenital malformations, causes lifelong neurological complications, particularly in terms of motor dysfunction. Fetuses with SBA exhibit voluntary leg movements in utero and during early neonatal life, but these disappear within the first few weeks...

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Bibliographic Details
Main Authors: Md. Sakirul Islam Khan, Hiroaki Nabeka, Farzana Islam, Tetsuya Shimokawa, Shouichiro Saito, Xuan Li, Soichiro Kawabe, Fumihiko Hamada, Tetsuya Tachibana, Seiji Matsuda
Format: Article
Language:English
Published: The Company of Biologists 2017-12-01
Series:Disease Models & Mechanisms
Subjects:
Neural tube defect
Chicken model
Synaptic inputs
GABAergic transmission
Neurodegeneration
Motor dysfunction
Online Access:http://dmm.biologists.org/content/10/12/1421

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