Intracardiac thrombus in Behçet’s disease
Behçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet’s disease, we selected those with ICT. All patients fulfilled the diagnostic criteria of the International Study Group of Behçet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-12-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/887 |
| _version_ | 1818547778862710784 |
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| author | I. Ben Ghorbel N. Belfeki M.H. Houman |
| author_facet | I. Ben Ghorbel N. Belfeki M.H. Houman |
| author_sort | I. Ben Ghorbel |
| collection | DOAJ |
| description | Behçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet’s disease, we selected those with ICT. All patients fulfilled the diagnostic criteria of the International Study Group of Behçet’s disease. The ICT in each case was confirmed by ultrasonography, computed tomography and MRI. Clinical features and laboratory parameters were determined. Among our 518 patients with BD, 8 were diagnosed as having intracardiac thrombus (ICT). All were male; the mean age at the time of the ICT diagnosis was 30.8 years. The main presenting symptoms were hemoptysis, chest pain, and dyspnea. It was associated with pulmonary artery aneurysm and vena cava thrombosis in 3 cases each, pulmonary embolism, and lower limbs deep venous thrombosis in 1 case each. The coexistence of other cardiac complications was as follows: pericarditis in 2 cases, myocarditis, endomyocardial fibrosis, and coronary arteritis with consequent myocardial infarction in one case each. In all cases, echocardiography was sufficient to reach the diagnosis. Chest computed tomography performed in all cases led to the diagnosis of associated pulmonary vasculo-Behçet lesions in 4 cases. All patients received colchicine, anticoagulation, and corticosteroids. Seven patients were on immunosuppressant agents (2 patients received azathioprine and 5 cyclophosphamide). Clinical remission with ICT resolution was observed in 5 cases. Combined immunosuppressive therapy with prednisone and cyclophosphamide might be needed to treat ICT due to BD. |
| first_indexed | 2024-12-12T08:11:14Z |
| format | Article |
| id | doaj.art-ba43b31f58104571ab0dbcf988a7f586 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-12-12T08:11:14Z |
| publishDate | 2016-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-ba43b31f58104571ab0dbcf988a7f5862022-12-22T00:31:46ZengPAGEPress PublicationsReumatismo0048-74492240-26832016-12-0168314815310.4081/reumatismo.2016.887721Intracardiac thrombus in Behçet’s diseaseI. Ben Ghorbel0N. Belfeki1M.H. Houman2Department of Internal Medicine, University Hospital of La Rabta, TunisDepartment of Internal Medicine, University Hospital of La Rabta, TunisDepartment of Internal Medicine, University Hospital of La Rabta, TunisBehçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet’s disease, we selected those with ICT. All patients fulfilled the diagnostic criteria of the International Study Group of Behçet’s disease. The ICT in each case was confirmed by ultrasonography, computed tomography and MRI. Clinical features and laboratory parameters were determined. Among our 518 patients with BD, 8 were diagnosed as having intracardiac thrombus (ICT). All were male; the mean age at the time of the ICT diagnosis was 30.8 years. The main presenting symptoms were hemoptysis, chest pain, and dyspnea. It was associated with pulmonary artery aneurysm and vena cava thrombosis in 3 cases each, pulmonary embolism, and lower limbs deep venous thrombosis in 1 case each. The coexistence of other cardiac complications was as follows: pericarditis in 2 cases, myocarditis, endomyocardial fibrosis, and coronary arteritis with consequent myocardial infarction in one case each. In all cases, echocardiography was sufficient to reach the diagnosis. Chest computed tomography performed in all cases led to the diagnosis of associated pulmonary vasculo-Behçet lesions in 4 cases. All patients received colchicine, anticoagulation, and corticosteroids. Seven patients were on immunosuppressant agents (2 patients received azathioprine and 5 cyclophosphamide). Clinical remission with ICT resolution was observed in 5 cases. Combined immunosuppressive therapy with prednisone and cyclophosphamide might be needed to treat ICT due to BD.http://www.reumatismo.org/index.php/reuma/article/view/887Behçet’s diseaseIntracardiac thrombus. |
| spellingShingle | I. Ben Ghorbel N. Belfeki M.H. Houman Intracardiac thrombus in Behçet’s disease Reumatismo Behçet’s disease Intracardiac thrombus. |
| title | Intracardiac thrombus in Behçet’s disease |
| title_full | Intracardiac thrombus in Behçet’s disease |
| title_fullStr | Intracardiac thrombus in Behçet’s disease |
| title_full_unstemmed | Intracardiac thrombus in Behçet’s disease |
| title_short | Intracardiac thrombus in Behçet’s disease |
| title_sort | intracardiac thrombus in behcet s disease |
| topic | Behçet’s disease Intracardiac thrombus. |
| url | http://www.reumatismo.org/index.php/reuma/article/view/887 |
| work_keys_str_mv | AT ibenghorbel intracardiacthrombusinbehcetsdisease AT nbelfeki intracardiacthrombusinbehcetsdisease AT mhhouman intracardiacthrombusinbehcetsdisease |