Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs

AbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with beh...

Full description

Bibliographic Details
Main Authors: Marissa R Keever-Keigher, Pan Zhang, Courtni R Bolt, Haley E Rymut, Adrienne M Antonson, Megan P Caputo, Alexandra K Houser, Alvaro G Hernandez, Bruce R Southey, Laurie A Rund, Rodney W Johnson, Sandra L Rodriguez-Zas
Format: Article
Language:English
Published: Oxford University Press 2021-04-01
Series:G3: Genes, Genomes, Genetics
Online Access:https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab113
Description
Summary:AbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with behavior disorders and molecular changes in the amygdala of the offspring. This study advances the understanding of the effects of pre- and postnatal stressors in amygdala gene networks. The amygdala transcriptome was profiled on female and male pigs that were either exposed to viral-elicited MIA or not and were weaned or nursed. Overall, 111 genes presented interacting or independent effects of weaning, MIA, or sex (FDR-adjusted P
ISSN:2160-1836