Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs
AbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with beh...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2021-04-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab113 |
| _version_ | 1818775003466825728 |
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| author | Marissa R Keever-Keigher Pan Zhang Courtni R Bolt Haley E Rymut Adrienne M Antonson Megan P Caputo Alexandra K Houser Alvaro G Hernandez Bruce R Southey Laurie A Rund Rodney W Johnson Sandra L Rodriguez-Zas |
| author_facet | Marissa R Keever-Keigher Pan Zhang Courtni R Bolt Haley E Rymut Adrienne M Antonson Megan P Caputo Alexandra K Houser Alvaro G Hernandez Bruce R Southey Laurie A Rund Rodney W Johnson Sandra L Rodriguez-Zas |
| author_sort | Marissa R Keever-Keigher |
| collection | DOAJ |
| description | AbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with behavior disorders and molecular changes in the amygdala of the offspring. This study advances the understanding of the effects of pre- and postnatal stressors in amygdala gene networks. The amygdala transcriptome was profiled on female and male pigs that were either exposed to viral-elicited MIA or not and were weaned or nursed. Overall, 111 genes presented interacting or independent effects of weaning, MIA, or sex (FDR-adjusted P |
| first_indexed | 2024-12-18T10:50:08Z |
| format | Article |
| id | doaj.art-ba441c060b314d8ab57b272f8115125d |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-12-18T10:50:08Z |
| publishDate | 2021-04-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-ba441c060b314d8ab57b272f8115125d2022-12-21T21:10:28ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362021-04-0111810.1093/g3journal/jkab113Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigsMarissa R Keever-Keigher0Pan Zhang1Courtni R Bolt2Haley E Rymut3Adrienne M Antonson4Megan P Caputo5Alexandra K Houser6Alvaro G Hernandez7Bruce R Southey8Laurie A Rund9Rodney W Johnson10Sandra L Rodriguez-Zas11https://orcid.org/0000-0003-1122-4758Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USAIllinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USAHigh-Throughput Sequencing and Genotyping Unit, Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USADepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USAAbstractChanges at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with behavior disorders and molecular changes in the amygdala of the offspring. This study advances the understanding of the effects of pre- and postnatal stressors in amygdala gene networks. The amygdala transcriptome was profiled on female and male pigs that were either exposed to viral-elicited MIA or not and were weaned or nursed. Overall, 111 genes presented interacting or independent effects of weaning, MIA, or sex (FDR-adjusted Phttps://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab113 |
| spellingShingle | Marissa R Keever-Keigher Pan Zhang Courtni R Bolt Haley E Rymut Adrienne M Antonson Megan P Caputo Alexandra K Houser Alvaro G Hernandez Bruce R Southey Laurie A Rund Rodney W Johnson Sandra L Rodriguez-Zas Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs G3: Genes, Genomes, Genetics |
| title | Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| title_full | Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| title_fullStr | Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| title_full_unstemmed | Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| title_short | Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| title_sort | interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab113 |
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