Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer
Aim: To investigate the prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer. Patients and Methods: A total of forty-nine male patients aged between 42 and 84 years with advanced prostate cancer receiving therapy of maximum androgen blo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2005-01-01
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| Series: | International Journal of Medicine and Health Development |
| Subjects: | |
| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2005;volume=10;issue=1;spage=53;epage=57;aulast=Aghaji;type=0 |
| _version_ | 1798018684911878144 |
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| author | A E Aghaji J O Ohaju-Obodo D N Osegbe H N Mbibu H Maitama |
| author_facet | A E Aghaji J O Ohaju-Obodo D N Osegbe H N Mbibu H Maitama |
| author_sort | A E Aghaji |
| collection | DOAJ |
| description | Aim: To investigate the prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer.
Patients and Methods: A total of forty-nine male patients aged between 42 and 84 years with advanced prostate cancer receiving therapy of maximum androgen bloackade were enrolled and had their serum prostate specific antigen value and rate of change assessed over a period of 48 weeks.
Results: The rate of change of prostate specific antigen at week 12 of the 40 patients with response (complete/partial) shows that the PSA level at week 12 had changed (reduced) by an average of 122% from the baseline value, while the median rate of change was 97% compared to patients with either no change/progression of disease status whose PSA level at week 12 had changed by only 11.7% and the median rate of change was 0%.
Conclusion: It could therefore be concluded that PSA rate of change is of prognostic significance in patients with advanced prostatic cancer. |
| first_indexed | 2024-04-11T16:28:27Z |
| format | Article |
| id | doaj.art-ba4505557d6b48f4a77c633fdee88608 |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-11T16:28:27Z |
| publishDate | 2005-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-ba4505557d6b48f4a77c633fdee886082022-12-22T04:14:07ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952005-01-011015357Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancerA E AghajiJ O Ohaju-ObodoD N OsegbeH N MbibuH MaitamaAim: To investigate the prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer. Patients and Methods: A total of forty-nine male patients aged between 42 and 84 years with advanced prostate cancer receiving therapy of maximum androgen bloackade were enrolled and had their serum prostate specific antigen value and rate of change assessed over a period of 48 weeks. Results: The rate of change of prostate specific antigen at week 12 of the 40 patients with response (complete/partial) shows that the PSA level at week 12 had changed (reduced) by an average of 122% from the baseline value, while the median rate of change was 97% compared to patients with either no change/progression of disease status whose PSA level at week 12 had changed by only 11.7% and the median rate of change was 0%. Conclusion: It could therefore be concluded that PSA rate of change is of prognostic significance in patients with advanced prostatic cancer.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2005;volume=10;issue=1;spage=53;epage=57;aulast=Aghaji;type=0advanced prostate cancerprostate specific antigen (psa)rate of change of psaprognostic significance |
| spellingShingle | A E Aghaji J O Ohaju-Obodo D N Osegbe H N Mbibu H Maitama Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer International Journal of Medicine and Health Development advanced prostate cancer prostate specific antigen (psa) rate of change of psa prognostic significance |
| title | Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer |
| title_full | Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer |
| title_fullStr | Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer |
| title_full_unstemmed | Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer |
| title_short | Prognostic significance of Prostate-Specific Antigen (PSA) rate of change in patients with advanced prostate cancer |
| title_sort | prognostic significance of prostate specific antigen psa rate of change in patients with advanced prostate cancer |
| topic | advanced prostate cancer prostate specific antigen (psa) rate of change of psa prognostic significance |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2005;volume=10;issue=1;spage=53;epage=57;aulast=Aghaji;type=0 |
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