Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015)
Abstract Background Pneumococcal disease caused by Streptococcus pneumoniae is an important cause of morbidity and mortality across all ages, particularly in younger children and older adults. Here, we describe pneumococcal disease hospitalizations at Ministry of Health (MoH) facilities in Malaysia...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08611-3 |
| _version_ | 1797355944689008640 |
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| author | Saravanan S. R. Sundaramurthy Kristen E. Allen Mark A. Fletcher Kok Fui Liew Boekhtiar Borhanuddin Mohammad Ali Graciela Morales Bradford Gessner Jerusha Naidoo Jo Southern |
| author_facet | Saravanan S. R. Sundaramurthy Kristen E. Allen Mark A. Fletcher Kok Fui Liew Boekhtiar Borhanuddin Mohammad Ali Graciela Morales Bradford Gessner Jerusha Naidoo Jo Southern |
| author_sort | Saravanan S. R. Sundaramurthy |
| collection | DOAJ |
| description | Abstract Background Pneumococcal disease caused by Streptococcus pneumoniae is an important cause of morbidity and mortality across all ages, particularly in younger children and older adults. Here, we describe pneumococcal disease hospitalizations at Ministry of Health (MoH) facilities in Malaysia between 2013 and 2015. Methods This was a retrospective databases analysis. Tabular data from the Malaysian Health Data Warehouse (MyHDW) were used to identify microbiologically confirmed, pneumococcal disease hospitalizations and deaths during hospitalization, using hospital-assigned ICD-10 codes (i.e., classified as meningitis, pneumonia, or non-meningitis non-pneumonia). Case counts, mortality counts, and case fatality rates were reported by patient age group and by Malaysian geographic region. Results A total of 683 pneumococcal disease hospitalizations were identified from the analysis: 53 pneumococcal meningitis hospitalizations (5 deaths and 48 discharges), 413 pneumococcal pneumonia hospitalizations (24 deaths and 389 discharges), and 205 non-meningitis non-pneumonia pneumococcal disease hospitalizations (58 deaths and 147 discharges). Most hospitalizations occurred in children aged < 2 years. Crude mortality was highest among children aged < 2 years (for all three disease categories), among adults aged ≥ 65 years (for pneumococcal pneumonia), or among adults aged 65–85 years (for non-meningitis non-pneumonia pneumococcal disease). The case fatality rate, all ages included, was 5.8% for pneumococcal pneumonia, 9.1% for pneumococcal meningitis, and 28.3% for non-meningitis non-pneumonia pneumococcal disease. Conclusions Our study is the first to document pneumococcal disease hospitalizations and deaths during hospitalization in Malaysia. Although this database analysis likely underestimated case counts, and the true disease burden could be even greater, the study demonstrates a substantial burden of pneumococcal disease. Public health measures, including vaccination, would significantly contribute to the prevention of hospitalizations and deaths associated with pneumococcal disease in Malaysia. |
| first_indexed | 2024-03-08T14:19:29Z |
| format | Article |
| id | doaj.art-ba4615a9d3e54778a172e4d8d67fdee4 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T14:19:29Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ba4615a9d3e54778a172e4d8d67fdee42024-01-14T12:13:20ZengBMCBMC Infectious Diseases1471-23342024-01-012411810.1186/s12879-023-08611-3Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015)Saravanan S. R. Sundaramurthy0Kristen E. Allen1Mark A. Fletcher2Kok Fui Liew3Boekhtiar Borhanuddin4Mohammad Ali5Graciela Morales6Bradford Gessner7Jerusha Naidoo8Jo Southern9Malaysian Association for Family and Child Health (MAFCH)Vaccines Medical and Scientific Affairs, Pfizer BiopharmaEmerging Markets Region Medical AffairsPfizer BiopharmaMalaysian Association for Family and Child Health (MAFCH)Vaccines Medical and Scientific Affairs, Pfizer BiopharmaEmerging Markets Region Medical AffairsVaccines Medical and Scientific Affairs, Pfizer BiopharmaEmerging Markets Region Medical AffairsVaccines Medical and Scientific Affairs, Pfizer BiopharmaAbstract Background Pneumococcal disease caused by Streptococcus pneumoniae is an important cause of morbidity and mortality across all ages, particularly in younger children and older adults. Here, we describe pneumococcal disease hospitalizations at Ministry of Health (MoH) facilities in Malaysia between 2013 and 2015. Methods This was a retrospective databases analysis. Tabular data from the Malaysian Health Data Warehouse (MyHDW) were used to identify microbiologically confirmed, pneumococcal disease hospitalizations and deaths during hospitalization, using hospital-assigned ICD-10 codes (i.e., classified as meningitis, pneumonia, or non-meningitis non-pneumonia). Case counts, mortality counts, and case fatality rates were reported by patient age group and by Malaysian geographic region. Results A total of 683 pneumococcal disease hospitalizations were identified from the analysis: 53 pneumococcal meningitis hospitalizations (5 deaths and 48 discharges), 413 pneumococcal pneumonia hospitalizations (24 deaths and 389 discharges), and 205 non-meningitis non-pneumonia pneumococcal disease hospitalizations (58 deaths and 147 discharges). Most hospitalizations occurred in children aged < 2 years. Crude mortality was highest among children aged < 2 years (for all three disease categories), among adults aged ≥ 65 years (for pneumococcal pneumonia), or among adults aged 65–85 years (for non-meningitis non-pneumonia pneumococcal disease). The case fatality rate, all ages included, was 5.8% for pneumococcal pneumonia, 9.1% for pneumococcal meningitis, and 28.3% for non-meningitis non-pneumonia pneumococcal disease. Conclusions Our study is the first to document pneumococcal disease hospitalizations and deaths during hospitalization in Malaysia. Although this database analysis likely underestimated case counts, and the true disease burden could be even greater, the study demonstrates a substantial burden of pneumococcal disease. Public health measures, including vaccination, would significantly contribute to the prevention of hospitalizations and deaths associated with pneumococcal disease in Malaysia.https://doi.org/10.1186/s12879-023-08611-3PneumococcalPneumoniaMeningitisSepticaemiaBacteraemiaMalaysia |
| spellingShingle | Saravanan S. R. Sundaramurthy Kristen E. Allen Mark A. Fletcher Kok Fui Liew Boekhtiar Borhanuddin Mohammad Ali Graciela Morales Bradford Gessner Jerusha Naidoo Jo Southern Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) BMC Infectious Diseases Pneumococcal Pneumonia Meningitis Septicaemia Bacteraemia Malaysia |
| title | Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) |
| title_full | Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) |
| title_fullStr | Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) |
| title_full_unstemmed | Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) |
| title_short | Retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the Malaysian healthcare system over a 3-year period (2013–2015) |
| title_sort | retrospective database analysis for clinical diagnoses commonly associated with pneumococcal diseases in the malaysian healthcare system over a 3 year period 2013 2015 |
| topic | Pneumococcal Pneumonia Meningitis Septicaemia Bacteraemia Malaysia |
| url | https://doi.org/10.1186/s12879-023-08611-3 |
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