Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis

Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational acti...

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Bibliographic Details
Main Authors: Kristina Hertzler-Schaefer, Grinu Mathew, Ally-Khan Somani, Sunil Tholpady, Madhavi P. Kadakia, Yiping Chen, Dan F. Spandau, Xin Zhang
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714000795

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