Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe.
<h4>Setting</h4>Four primary health care clinics providing tuberculosis (TB) and Human Immunodeficiency Virus care services in Bulawayo, Zimbabwe.<h4>Objectives</h4>To assess isoniazid preventive therapy (IPT) initiation and completion, factors associated with IPT uptake and...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0223076 |
| _version_ | 1819143746777776128 |
|---|---|
| author | Saziso Nyathi Riitta A Dlodlo Srinath Satyanarayana Kudakwashe C Takarinda Hannock Tweya Sithokozile Hove Ronnie Matambo Winnie Mandewo Khulamuzi Nyathi Edwin Sibanda Anthony D Harries |
| author_facet | Saziso Nyathi Riitta A Dlodlo Srinath Satyanarayana Kudakwashe C Takarinda Hannock Tweya Sithokozile Hove Ronnie Matambo Winnie Mandewo Khulamuzi Nyathi Edwin Sibanda Anthony D Harries |
| author_sort | Saziso Nyathi |
| collection | DOAJ |
| description | <h4>Setting</h4>Four primary health care clinics providing tuberculosis (TB) and Human Immunodeficiency Virus care services in Bulawayo, Zimbabwe.<h4>Objectives</h4>To assess isoniazid preventive therapy (IPT) initiation and completion, factors associated with IPT uptake and incidence of TB, and TB and antiretroviral treatment (ART) outcomes among people living with HIV (PLHIV).<h4>Design</h4>This was a cohort study using routine data in the records for PLHIV initiated on ART from October 2013 to March 2014 with 31 December 2017 as the end of the follow-up period.<h4>Results</h4>A total of 408 PLHIV were eligible for IPT, 214 (52%) were initiated on IPT and 201 (94%) completed IPT. No person in the IPT-initiated group developed Tuberculosis (TB). Six persons with TB were reported among the non-IPT-initiated group leading to an incidence of 9 cases/1,000 person-years of follow-up. About 70% of those who developed and were treated for TB had a successful TB treatment outcome. The survival on ART at four years of follow-up was 88% among the IPT-initiated PLHIV that was significantly higher than the 75% survival in the group not- initiated on IPT.<h4>Conclusion</h4>The study revealed low IPT initiation among eligible PLHIV who, if started on IPT, completed the six month regimen. TB was reported only among the PLHIV not-initiated on IPT and the four year ART survival was higher in the IPT-initiated group than in the non-initiated group. These findings reinforce the need to strengthen IPT uptake among PLHIV in Bulawayo. |
| first_indexed | 2024-12-22T12:31:09Z |
| format | Article |
| id | doaj.art-ba470b498ca343f496721f99c3f6e63c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T12:31:09Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ba470b498ca343f496721f99c3f6e63c2022-12-21T18:25:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-011410e022307610.1371/journal.pone.0223076Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe.Saziso NyathiRiitta A DlodloSrinath SatyanarayanaKudakwashe C TakarindaHannock TweyaSithokozile HoveRonnie MatamboWinnie MandewoKhulamuzi NyathiEdwin SibandaAnthony D Harries<h4>Setting</h4>Four primary health care clinics providing tuberculosis (TB) and Human Immunodeficiency Virus care services in Bulawayo, Zimbabwe.<h4>Objectives</h4>To assess isoniazid preventive therapy (IPT) initiation and completion, factors associated with IPT uptake and incidence of TB, and TB and antiretroviral treatment (ART) outcomes among people living with HIV (PLHIV).<h4>Design</h4>This was a cohort study using routine data in the records for PLHIV initiated on ART from October 2013 to March 2014 with 31 December 2017 as the end of the follow-up period.<h4>Results</h4>A total of 408 PLHIV were eligible for IPT, 214 (52%) were initiated on IPT and 201 (94%) completed IPT. No person in the IPT-initiated group developed Tuberculosis (TB). Six persons with TB were reported among the non-IPT-initiated group leading to an incidence of 9 cases/1,000 person-years of follow-up. About 70% of those who developed and were treated for TB had a successful TB treatment outcome. The survival on ART at four years of follow-up was 88% among the IPT-initiated PLHIV that was significantly higher than the 75% survival in the group not- initiated on IPT.<h4>Conclusion</h4>The study revealed low IPT initiation among eligible PLHIV who, if started on IPT, completed the six month regimen. TB was reported only among the PLHIV not-initiated on IPT and the four year ART survival was higher in the IPT-initiated group than in the non-initiated group. These findings reinforce the need to strengthen IPT uptake among PLHIV in Bulawayo.https://doi.org/10.1371/journal.pone.0223076 |
| spellingShingle | Saziso Nyathi Riitta A Dlodlo Srinath Satyanarayana Kudakwashe C Takarinda Hannock Tweya Sithokozile Hove Ronnie Matambo Winnie Mandewo Khulamuzi Nyathi Edwin Sibanda Anthony D Harries Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. PLoS ONE |
| title | Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. |
| title_full | Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. |
| title_fullStr | Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. |
| title_full_unstemmed | Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. |
| title_short | Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe. |
| title_sort | isoniazid preventive therapy uptake incidence of tuberculosis and survival among people living with hiv in bulawayo zimbabwe |
| url | https://doi.org/10.1371/journal.pone.0223076 |
| work_keys_str_mv | AT sazisonyathi isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT riittaadlodlo isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT srinathsatyanarayana isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT kudakwashectakarinda isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT hannocktweya isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT sithokozilehove isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT ronniematambo isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT winniemandewo isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT khulamuzinyathi isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT edwinsibanda isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe AT anthonydharries isoniazidpreventivetherapyuptakeincidenceoftuberculosisandsurvivalamongpeoplelivingwithhivinbulawayozimbabwe |