Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination
Guillain-Barre syndrome (GBS) following a SARS-CoV-2 vaccination has been repeatedly observed but GBS following a SARS-CoV-2 infection in a vaccinated patient has not been reported.A 69yo female developed paresthesias of both lower and upper limbs which were followed by progressive muscle weakness....
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250921001827 |
| _version_ | 1819129359931277312 |
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| author | Josef Finsterer |
| author_facet | Josef Finsterer |
| author_sort | Josef Finsterer |
| collection | DOAJ |
| description | Guillain-Barre syndrome (GBS) following a SARS-CoV-2 vaccination has been repeatedly observed but GBS following a SARS-CoV-2 infection in a vaccinated patient has not been reported.A 69yo female developed paresthesias of both lower and upper limbs which were followed by progressive muscle weakness. The history was positive for a mild SARS-CoV-2 infection 15 days earlier. COVID-19 occurred despite a first dose of a vector-based SARS-CoV-2 vaccine, 40 days prior to onset of GBS. Since CSF investigations and nerve conduction studies were indicative of GBS, subtype acute, inflammatory, demyelinating polyneuropathy (AIDP), immunoglobulins (30 g/d) were started. After two weeks complete recovery was achieved.In conclusion, SARS-CoV-2 infections may develop despite full vaccination and may be complicated by GBS. Since no other trigger of GBS could be identified, a causal relation between the SARS-CoV-2 infection and GBS was suspected. |
| first_indexed | 2024-12-22T08:42:28Z |
| format | Article |
| id | doaj.art-ba4aa589ced849aeb62c5bb270f7125f |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-22T08:42:28Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-ba4aa589ced849aeb62c5bb270f7125f2022-12-21T18:32:12ZengElsevierIDCases2214-25092021-01-0125e01226Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccinationJosef Finsterer0Klinik Landstrasse, Messerli Institute, Postfach 20, 1180, Vienna, AustriaGuillain-Barre syndrome (GBS) following a SARS-CoV-2 vaccination has been repeatedly observed but GBS following a SARS-CoV-2 infection in a vaccinated patient has not been reported.A 69yo female developed paresthesias of both lower and upper limbs which were followed by progressive muscle weakness. The history was positive for a mild SARS-CoV-2 infection 15 days earlier. COVID-19 occurred despite a first dose of a vector-based SARS-CoV-2 vaccine, 40 days prior to onset of GBS. Since CSF investigations and nerve conduction studies were indicative of GBS, subtype acute, inflammatory, demyelinating polyneuropathy (AIDP), immunoglobulins (30 g/d) were started. After two weeks complete recovery was achieved.In conclusion, SARS-CoV-2 infections may develop despite full vaccination and may be complicated by GBS. Since no other trigger of GBS could be identified, a causal relation between the SARS-CoV-2 infection and GBS was suspected.http://www.sciencedirect.com/science/article/pii/S2214250921001827SARS-CoV-2COVID-19PolyradiculitisVaccinationAdverse reactionSide effect |
| spellingShingle | Josef Finsterer Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination IDCases SARS-CoV-2 COVID-19 Polyradiculitis Vaccination Adverse reaction Side effect |
| title | Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination |
| title_full | Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination |
| title_fullStr | Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination |
| title_full_unstemmed | Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination |
| title_short | Guillain-Barre syndrome 15 days after COVID-19 despite SARS-CoV-2 vaccination |
| title_sort | guillain barre syndrome 15 days after covid 19 despite sars cov 2 vaccination |
| topic | SARS-CoV-2 COVID-19 Polyradiculitis Vaccination Adverse reaction Side effect |
| url | http://www.sciencedirect.com/science/article/pii/S2214250921001827 |
| work_keys_str_mv | AT joseffinsterer guillainbarresyndrome15daysaftercovid19despitesarscov2vaccination |