Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients
Abstract Purpose To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Methods Twenty-eight patients with ER-positive...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-12-01
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| Series: | European Journal of Hybrid Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41824-023-00176-3 |
| _version_ | 1797377220934631424 |
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| author | Peerapon Kiatkittikul Supanida Mayurasakorn Chetsadaporn Promteangtrong Anchisa Kunawudhi Dheeratama Siripongsatian Natdanai Hirata Attapon Jantarato Natphimol Boonkawin Sukanya Yaset Pattanapong Kongsakorn Warunya Phewnual Chanisa Chotipanich |
| author_facet | Peerapon Kiatkittikul Supanida Mayurasakorn Chetsadaporn Promteangtrong Anchisa Kunawudhi Dheeratama Siripongsatian Natdanai Hirata Attapon Jantarato Natphimol Boonkawin Sukanya Yaset Pattanapong Kongsakorn Warunya Phewnual Chanisa Chotipanich |
| author_sort | Peerapon Kiatkittikul |
| collection | DOAJ |
| description | Abstract Purpose To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Methods Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers. Semiquantitative parameters of maximum standardized uptake value (SUVmax) and tumor-to-normal ratio (T/N ratio) were compared using Wilcoxon signed-rank test. Factors potentially affecting the degree of radiotracer uptake were analyzed by multi-level linear regression analysis. Results The overall diagnostic performance of 18F-FES was comparable to 18F-FDG, except for higher specificity and NPV, with sensitivity, specificity, PPV, NPV, and accuracy of 87.56%, 100%, 100%, 35.14%, and 88.35%, respectively, for 18F-FES and 83.94%, 30.77%, 94.74%, 11.43%, and 95.37%, respectively, for 18F-FDG. Diagnostic performance of strong ER expression was better in 18F-FES but worse for 18F-FDG. There was a correlation of mucinous cell type and Allred score 7–8 with 18F-FES uptake, with correlation coefficients of 26.65 (19.28, 34.02), 5.90 (− 0.005, 11.81), and p-value of < 0.001, 0.05, respectively. Meanwhile, luminal B and Ki-67 were related to 18F-FDG uptake, with correlation coefficients of 2.76 (1.10, 0.20), 0.11 (0.01, 0.2), and p-value of 0.018, 0.025, respectively. Conclusion Diagnostic performance of 18F-FES is comparable to 18F-FDG, but better for strongly ER-positive breast cancer. Combination of 18F-FES and 18F-FDG would potentially overcome the limitations of each tracer with more accurate staging. |
| first_indexed | 2024-03-08T19:50:36Z |
| format | Article |
| id | doaj.art-ba4b19e740a1465281c06854477c4469 |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-03-08T19:50:36Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-ba4b19e740a1465281c06854477c44692023-12-24T12:08:02ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362023-12-017111310.1186/s41824-023-00176-3Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patientsPeerapon Kiatkittikul0Supanida Mayurasakorn1Chetsadaporn Promteangtrong2Anchisa Kunawudhi3Dheeratama Siripongsatian4Natdanai Hirata5Attapon Jantarato6Natphimol Boonkawin7Sukanya Yaset8Pattanapong Kongsakorn9Warunya Phewnual10Chanisa Chotipanich11National Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyNational Cyclotron and PET Centre, Chulabhorn Hospital, Chulabhorn Royal AcademyAbstract Purpose To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Methods Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers. Semiquantitative parameters of maximum standardized uptake value (SUVmax) and tumor-to-normal ratio (T/N ratio) were compared using Wilcoxon signed-rank test. Factors potentially affecting the degree of radiotracer uptake were analyzed by multi-level linear regression analysis. Results The overall diagnostic performance of 18F-FES was comparable to 18F-FDG, except for higher specificity and NPV, with sensitivity, specificity, PPV, NPV, and accuracy of 87.56%, 100%, 100%, 35.14%, and 88.35%, respectively, for 18F-FES and 83.94%, 30.77%, 94.74%, 11.43%, and 95.37%, respectively, for 18F-FDG. Diagnostic performance of strong ER expression was better in 18F-FES but worse for 18F-FDG. There was a correlation of mucinous cell type and Allred score 7–8 with 18F-FES uptake, with correlation coefficients of 26.65 (19.28, 34.02), 5.90 (− 0.005, 11.81), and p-value of < 0.001, 0.05, respectively. Meanwhile, luminal B and Ki-67 were related to 18F-FDG uptake, with correlation coefficients of 2.76 (1.10, 0.20), 0.11 (0.01, 0.2), and p-value of 0.018, 0.025, respectively. Conclusion Diagnostic performance of 18F-FES is comparable to 18F-FDG, but better for strongly ER-positive breast cancer. Combination of 18F-FES and 18F-FDG would potentially overcome the limitations of each tracer with more accurate staging.https://doi.org/10.1186/s41824-023-00176-318F-FES18F-FDG18F-fluroestradiol18F-flurodeoxyglucoseER-positive breast cancerInitial staging |
| spellingShingle | Peerapon Kiatkittikul Supanida Mayurasakorn Chetsadaporn Promteangtrong Anchisa Kunawudhi Dheeratama Siripongsatian Natdanai Hirata Attapon Jantarato Natphimol Boonkawin Sukanya Yaset Pattanapong Kongsakorn Warunya Phewnual Chanisa Chotipanich Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients European Journal of Hybrid Imaging 18F-FES 18F-FDG 18F-fluroestradiol 18F-flurodeoxyglucose ER-positive breast cancer Initial staging |
| title | Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients |
| title_full | Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients |
| title_fullStr | Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients |
| title_full_unstemmed | Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients |
| title_short | Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients |
| title_sort | head to head comparison of 18f fdg and 18f fes pet ct for initial staging of er positive breast cancer patients |
| topic | 18F-FES 18F-FDG 18F-fluroestradiol 18F-flurodeoxyglucose ER-positive breast cancer Initial staging |
| url | https://doi.org/10.1186/s41824-023-00176-3 |
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