Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Abstract Background Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer’s disease (AD), pathological tau accumulation correlates with cognitive decline. Substantial visual deficits are found in individuals affec...

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Bibliographic Details
Main Authors: Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Retinal ganglion cell
Tau
Axonal transport
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-017-0199-3

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