Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding

Background: The suitable BMI cut-off point in persons with endometrial cancer or hyperplasia with abnormal uterine bleeding was investigated in this study. Methods: This case-control research was conducted on 1470 women with abnormal uterine bleeding in Ayatollah Rouhani Hospital,Babol between 2010...

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Main Authors: Sara Alizadeh Garna, Shahla Yazdani, Hadis Mosavi, mohammad ranaei, Karimollah Hajian-Tilaki, Zinatossadat Bouzari
Format: Article
Language:English
Published: Babol University of Medical Sciences 2024-01-01
Series:Caspian Journal of Internal Medicine
Subjects:
Online Access:http://caspjim.com/article-1-3486-en.html
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author Sara Alizadeh Garna
Shahla Yazdani
Hadis Mosavi
mohammad ranaei
Karimollah Hajian-Tilaki
Zinatossadat Bouzari
author_facet Sara Alizadeh Garna
Shahla Yazdani
Hadis Mosavi
mohammad ranaei
Karimollah Hajian-Tilaki
Zinatossadat Bouzari
author_sort Sara Alizadeh Garna
collection DOAJ
description Background: The suitable BMI cut-off point in persons with endometrial cancer or hyperplasia with abnormal uterine bleeding was investigated in this study. Methods: This case-control research was conducted on 1470 women with abnormal uterine bleeding in Ayatollah Rouhani Hospital,Babol between 2010 and 2012, with 312 participants included in the study. In terms of uterine biopsy results, patients were split into six groups: simple hyperplasia without atypia, simple hyperplasia with atypia, complicated hyperplasia with atypia, complex hyperplasia without atypia, endometrial cancer, and normal persons. Results: The mean age and BMI of patients in these three groups were not significantly different (P equal to 0.081 and 0.435, respectively). The kind of disease exhibited a strong relationship with menstruation (P 0.001). The body mass index (BMI) values ​​did not have significant levels under the curve to determine the appropriate cut-off point in the diagnosis of hyperplasia plus endometrial cancer and endometrial cancer alone (P 0.380 and 0.124, respectively) and hyperplasia alone (P = 0.920). Based on logistic regression, age 50 years and older and irregular menstruation were significant with OR equal to 2.36 and 2.09 (P = 0.011) and HTN with OR equal to 0.44 (P = 0.026), respectively. Conclusion: BMI has little predictive value in the detection of endometrial cancer or hyperplasia, according to the findings, and other diagnostic and screening modalities should be utilized instead. The findings backed up the theory that old age and irregular menstruation are linked to an increased risk of endometrial cancer.
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spelling doaj.art-ba4ce8cba5064ba4a9afb19ff03d35862024-01-16T05:27:41ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722024-01-011518795Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine BleedingSara Alizadeh Garna0Shahla Yazdani1Hadis Mosavi2mohammad ranaei3Karimollah Hajian-Tilaki4Zinatossadat Bouzari5 Babol uiniverstiy of Medical scinces Babol uiniverstiy of Medical scinces Babol uiniverstiy of Medical scinces Babol uiniverstiy of Medical scinces Babol uiniverstiy of Medical scinces Babol uiniverstiy of Medical scinces Background: The suitable BMI cut-off point in persons with endometrial cancer or hyperplasia with abnormal uterine bleeding was investigated in this study. Methods: This case-control research was conducted on 1470 women with abnormal uterine bleeding in Ayatollah Rouhani Hospital,Babol between 2010 and 2012, with 312 participants included in the study. In terms of uterine biopsy results, patients were split into six groups: simple hyperplasia without atypia, simple hyperplasia with atypia, complicated hyperplasia with atypia, complex hyperplasia without atypia, endometrial cancer, and normal persons. Results: The mean age and BMI of patients in these three groups were not significantly different (P equal to 0.081 and 0.435, respectively). The kind of disease exhibited a strong relationship with menstruation (P 0.001). The body mass index (BMI) values ​​did not have significant levels under the curve to determine the appropriate cut-off point in the diagnosis of hyperplasia plus endometrial cancer and endometrial cancer alone (P 0.380 and 0.124, respectively) and hyperplasia alone (P = 0.920). Based on logistic regression, age 50 years and older and irregular menstruation were significant with OR equal to 2.36 and 2.09 (P = 0.011) and HTN with OR equal to 0.44 (P = 0.026), respectively. Conclusion: BMI has little predictive value in the detection of endometrial cancer or hyperplasia, according to the findings, and other diagnostic and screening modalities should be utilized instead. The findings backed up the theory that old age and irregular menstruation are linked to an increased risk of endometrial cancer.http://caspjim.com/article-1-3486-en.htmlabnormal uterine bleedingendometrial cancerendometrial hyperplasiabody mass indexinfertility.
spellingShingle Sara Alizadeh Garna
Shahla Yazdani
Hadis Mosavi
mohammad ranaei
Karimollah Hajian-Tilaki
Zinatossadat Bouzari
Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
Caspian Journal of Internal Medicine
abnormal uterine bleeding
endometrial cancer
endometrial hyperplasia
body mass index
infertility.
title Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
title_full Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
title_fullStr Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
title_full_unstemmed Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
title_short Predictive value of Body Mass Index (BMI) and Determination of optimum Cut-off Point in the diagnosis of endometrial hyperplasia in Pre-menopausal women with abnormal uterine Bleeding
title_sort predictive value of body mass index bmi and determination of optimum cut off point in the diagnosis of endometrial hyperplasia in pre menopausal women with abnormal uterine bleeding
topic abnormal uterine bleeding
endometrial cancer
endometrial hyperplasia
body mass index
infertility.
url http://caspjim.com/article-1-3486-en.html
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