A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
Abstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization betwe...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-08-01
|
Series: | Radiation Oncology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13014-019-1347-4 |
_version_ | 1818920157781688320 |
---|---|
author | Shintaro Shiba Kei Shibuya Hiroyuki Katoh Takuya Kaminuma Masaya Miyazaki Satoru Kakizaki Ken Shirabe Tatsuya Ohno Takashi Nakano |
author_facet | Shintaro Shiba Kei Shibuya Hiroyuki Katoh Takuya Kaminuma Masaya Miyazaki Satoru Kakizaki Ken Shirabe Tatsuya Ohno Takashi Nakano |
author_sort | Shintaro Shiba |
collection | DOAJ |
description | Abstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization between April 2007 and September 2016 were retrospectively reviewed. Treatment naïve patients with single HCC, who underwent carbon ion radiotherapy or transarterial chemoembolization as a primary treatment were included. Clinical outcomes of the treatments were compared after utilizing propensity score matching. Results Of 124 patients who received carbon ion radiotherapy and 353 patients who received transarterial chemoembolization, 31 and 23 patients met our inclusion criteria, respectively. After utilizing propensity score matching, 17 matched pairs of patients from each treatment group were analyzed. The median follow-up durations after carbon ion radiotherapy and transarterial chemoembolization were 43 and 32 months, respectively. The 3-year overall survival, local control, and progression-free survival rates in the carbon ion radiotherapy versus transarterial chemoembolization groups were 88% versus 58% (p < 0.05), 80% versus 26% (p < 0.01), and 51% versus 15% (p < 0.05), respectively. Conclusions Carbon ion radiotherapy showed more favorable clinical outcomes than did transarterial chemoembolization for patients with single hepatocellular carcinoma after matching patient characteristics utilizing propensity score matching. Further studies with larger patient numbers are required to confirm our results. Trial registration UMIN000036455: date of registration 22 March 2019, retrospectively registered. |
first_indexed | 2024-12-20T01:17:18Z |
format | Article |
id | doaj.art-ba4e84811fbf473cb406bc8783d7c971 |
institution | Directory Open Access Journal |
issn | 1748-717X |
language | English |
last_indexed | 2024-12-20T01:17:18Z |
publishDate | 2019-08-01 |
publisher | BMC |
record_format | Article |
series | Radiation Oncology |
spelling | doaj.art-ba4e84811fbf473cb406bc8783d7c9712022-12-21T19:58:33ZengBMCRadiation Oncology1748-717X2019-08-011411910.1186/s13014-019-1347-4A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching studyShintaro Shiba0Kei Shibuya1Hiroyuki Katoh2Takuya Kaminuma3Masaya Miyazaki4Satoru Kakizaki5Ken Shirabe6Tatsuya Ohno7Takashi Nakano8Department of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Kanagawa Cancer CenterDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Applied Medical Imaging, Gunma University Graduate School of MedicineDepartment of Gastroenterology and Hepatology Science, Gunma University Graduate School of MedicineDepartment of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of MedicineGunma University Heavy Ion Medical CenterDepartment of Radiation Oncology, Gunma University Graduate School of MedicineAbstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization between April 2007 and September 2016 were retrospectively reviewed. Treatment naïve patients with single HCC, who underwent carbon ion radiotherapy or transarterial chemoembolization as a primary treatment were included. Clinical outcomes of the treatments were compared after utilizing propensity score matching. Results Of 124 patients who received carbon ion radiotherapy and 353 patients who received transarterial chemoembolization, 31 and 23 patients met our inclusion criteria, respectively. After utilizing propensity score matching, 17 matched pairs of patients from each treatment group were analyzed. The median follow-up durations after carbon ion radiotherapy and transarterial chemoembolization were 43 and 32 months, respectively. The 3-year overall survival, local control, and progression-free survival rates in the carbon ion radiotherapy versus transarterial chemoembolization groups were 88% versus 58% (p < 0.05), 80% versus 26% (p < 0.01), and 51% versus 15% (p < 0.05), respectively. Conclusions Carbon ion radiotherapy showed more favorable clinical outcomes than did transarterial chemoembolization for patients with single hepatocellular carcinoma after matching patient characteristics utilizing propensity score matching. Further studies with larger patient numbers are required to confirm our results. Trial registration UMIN000036455: date of registration 22 March 2019, retrospectively registered.http://link.springer.com/article/10.1186/s13014-019-1347-4Carbon ion radiotherapyHepatocellular carcinomaTransarterial chemoembolizationPropensity score matching |
spellingShingle | Shintaro Shiba Kei Shibuya Hiroyuki Katoh Takuya Kaminuma Masaya Miyazaki Satoru Kakizaki Ken Shirabe Tatsuya Ohno Takashi Nakano A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study Radiation Oncology Carbon ion radiotherapy Hepatocellular carcinoma Transarterial chemoembolization Propensity score matching |
title | A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study |
title_full | A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study |
title_fullStr | A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study |
title_full_unstemmed | A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study |
title_short | A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study |
title_sort | comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma a propensity score matching study |
topic | Carbon ion radiotherapy Hepatocellular carcinoma Transarterial chemoembolization Propensity score matching |
url | http://link.springer.com/article/10.1186/s13014-019-1347-4 |
work_keys_str_mv | AT shintaroshiba acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT keishibuya acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT hiroyukikatoh acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT takuyakaminuma acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT masayamiyazaki acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT satorukakizaki acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT kenshirabe acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT tatsuyaohno acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT takashinakano acomparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT shintaroshiba comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT keishibuya comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT hiroyukikatoh comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT takuyakaminuma comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT masayamiyazaki comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT satorukakizaki comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT kenshirabe comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT tatsuyaohno comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy AT takashinakano comparisonofcarbonionradiotherapyandtransarterialchemoembolizationtreatmentoutcomesforsinglehepatocellularcarcinomaapropensityscorematchingstudy |