A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study

Abstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization betwe...

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Main Authors: Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Takuya Kaminuma, Masaya Miyazaki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno, Takashi Nakano
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Radiation Oncology
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Online Access:http://link.springer.com/article/10.1186/s13014-019-1347-4
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author Shintaro Shiba
Kei Shibuya
Hiroyuki Katoh
Takuya Kaminuma
Masaya Miyazaki
Satoru Kakizaki
Ken Shirabe
Tatsuya Ohno
Takashi Nakano
author_facet Shintaro Shiba
Kei Shibuya
Hiroyuki Katoh
Takuya Kaminuma
Masaya Miyazaki
Satoru Kakizaki
Ken Shirabe
Tatsuya Ohno
Takashi Nakano
author_sort Shintaro Shiba
collection DOAJ
description Abstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization between April 2007 and September 2016 were retrospectively reviewed. Treatment naïve patients with single HCC, who underwent carbon ion radiotherapy or transarterial chemoembolization as a primary treatment were included. Clinical outcomes of the treatments were compared after utilizing propensity score matching. Results Of 124 patients who received carbon ion radiotherapy and 353 patients who received transarterial chemoembolization, 31 and 23 patients met our inclusion criteria, respectively. After utilizing propensity score matching, 17 matched pairs of patients from each treatment group were analyzed. The median follow-up durations after carbon ion radiotherapy and transarterial chemoembolization were 43 and 32 months, respectively. The 3-year overall survival, local control, and progression-free survival rates in the carbon ion radiotherapy versus transarterial chemoembolization groups were 88% versus 58% (p < 0.05), 80% versus 26% (p < 0.01), and 51% versus 15% (p < 0.05), respectively. Conclusions Carbon ion radiotherapy showed more favorable clinical outcomes than did transarterial chemoembolization for patients with single hepatocellular carcinoma after matching patient characteristics utilizing propensity score matching. Further studies with larger patient numbers are required to confirm our results. Trial registration UMIN000036455: date of registration 22 March 2019, retrospectively registered.
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spelling doaj.art-ba4e84811fbf473cb406bc8783d7c9712022-12-21T19:58:33ZengBMCRadiation Oncology1748-717X2019-08-011411910.1186/s13014-019-1347-4A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching studyShintaro Shiba0Kei Shibuya1Hiroyuki Katoh2Takuya Kaminuma3Masaya Miyazaki4Satoru Kakizaki5Ken Shirabe6Tatsuya Ohno7Takashi Nakano8Department of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Kanagawa Cancer CenterDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Applied Medical Imaging, Gunma University Graduate School of MedicineDepartment of Gastroenterology and Hepatology Science, Gunma University Graduate School of MedicineDepartment of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of MedicineGunma University Heavy Ion Medical CenterDepartment of Radiation Oncology, Gunma University Graduate School of MedicineAbstract Background We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma. Methods Data of 477 patients with hepatocellular carcinoma who had undergone carbon ion radiotherapy or transarterial chemoembolization between April 2007 and September 2016 were retrospectively reviewed. Treatment naïve patients with single HCC, who underwent carbon ion radiotherapy or transarterial chemoembolization as a primary treatment were included. Clinical outcomes of the treatments were compared after utilizing propensity score matching. Results Of 124 patients who received carbon ion radiotherapy and 353 patients who received transarterial chemoembolization, 31 and 23 patients met our inclusion criteria, respectively. After utilizing propensity score matching, 17 matched pairs of patients from each treatment group were analyzed. The median follow-up durations after carbon ion radiotherapy and transarterial chemoembolization were 43 and 32 months, respectively. The 3-year overall survival, local control, and progression-free survival rates in the carbon ion radiotherapy versus transarterial chemoembolization groups were 88% versus 58% (p < 0.05), 80% versus 26% (p < 0.01), and 51% versus 15% (p < 0.05), respectively. Conclusions Carbon ion radiotherapy showed more favorable clinical outcomes than did transarterial chemoembolization for patients with single hepatocellular carcinoma after matching patient characteristics utilizing propensity score matching. Further studies with larger patient numbers are required to confirm our results. Trial registration UMIN000036455: date of registration 22 March 2019, retrospectively registered.http://link.springer.com/article/10.1186/s13014-019-1347-4Carbon ion radiotherapyHepatocellular carcinomaTransarterial chemoembolizationPropensity score matching
spellingShingle Shintaro Shiba
Kei Shibuya
Hiroyuki Katoh
Takuya Kaminuma
Masaya Miyazaki
Satoru Kakizaki
Ken Shirabe
Tatsuya Ohno
Takashi Nakano
A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
Radiation Oncology
Carbon ion radiotherapy
Hepatocellular carcinoma
Transarterial chemoembolization
Propensity score matching
title A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
title_full A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
title_fullStr A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
title_full_unstemmed A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
title_short A comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma: a propensity score matching study
title_sort comparison of carbon ion radiotherapy and transarterial chemoembolization treatment outcomes for single hepatocellular carcinoma a propensity score matching study
topic Carbon ion radiotherapy
Hepatocellular carcinoma
Transarterial chemoembolization
Propensity score matching
url http://link.springer.com/article/10.1186/s13014-019-1347-4
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