Regulation of Mitochondrial Function by the Actin Cytoskeleton
The regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXP...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.795838/full |
| _version_ | 1818871688232697856 |
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| author | María Illescas Ana Peñas Joaquín Arenas Joaquín Arenas Miguel A. Martín Miguel A. Martín Cristina Ugalde Cristina Ugalde |
| author_facet | María Illescas Ana Peñas Joaquín Arenas Joaquín Arenas Miguel A. Martín Miguel A. Martín Cristina Ugalde Cristina Ugalde |
| author_sort | María Illescas |
| collection | DOAJ |
| description | The regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXPHOS disorders through yet to be defined mechanisms. In this mini-review, we will summarize the experimental evidence supporting the fundamental roles of actin cytoskeleton and ABPs on mitochondrial trafficking, dynamics, biogenesis, metabolism and apoptosis, with a particular focus on Gelsolin involvement in mitochondrial disorders. The functional interplay between the actin cytoskeleton, ABPs and mitochondrial membranes for the regulation of cellular homeostasis thus emerges as a new exciting field for future research and therapeutic approaches. |
| first_indexed | 2024-12-19T12:26:53Z |
| format | Article |
| id | doaj.art-ba4eadc3c45b4dc383e4533b63bc772f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-19T12:26:53Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ba4eadc3c45b4dc383e4533b63bc772f2022-12-21T20:21:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-12-01910.3389/fcell.2021.795838795838Regulation of Mitochondrial Function by the Actin CytoskeletonMaría Illescas0Ana Peñas1Joaquín Arenas2Joaquín Arenas3Miguel A. Martín4Miguel A. Martín5Cristina Ugalde6Cristina Ugalde7Instituto de Investigación Hospital 12 de Octubre, Madrid, SpainInstituto de Investigación Hospital 12 de Octubre, Madrid, SpainInstituto de Investigación Hospital 12 de Octubre, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, SpainInstituto de Investigación Hospital 12 de Octubre, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, SpainInstituto de Investigación Hospital 12 de Octubre, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, SpainThe regulatory role of actin cytoskeleton on mitochondrial function is a growing research field, but the underlying molecular mechanisms remain poorly understood. Specific actin-binding proteins (ABPs), such as Gelsolin, have also been shown to participate in the pathophysiology of mitochondrial OXPHOS disorders through yet to be defined mechanisms. In this mini-review, we will summarize the experimental evidence supporting the fundamental roles of actin cytoskeleton and ABPs on mitochondrial trafficking, dynamics, biogenesis, metabolism and apoptosis, with a particular focus on Gelsolin involvement in mitochondrial disorders. The functional interplay between the actin cytoskeleton, ABPs and mitochondrial membranes for the regulation of cellular homeostasis thus emerges as a new exciting field for future research and therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fcell.2021.795838/fullmitochondriaactin cytoskeletonOXPHOS systemgelsolinmitochondrial disease |
| spellingShingle | María Illescas Ana Peñas Joaquín Arenas Joaquín Arenas Miguel A. Martín Miguel A. Martín Cristina Ugalde Cristina Ugalde Regulation of Mitochondrial Function by the Actin Cytoskeleton Frontiers in Cell and Developmental Biology mitochondria actin cytoskeleton OXPHOS system gelsolin mitochondrial disease |
| title | Regulation of Mitochondrial Function by the Actin Cytoskeleton |
| title_full | Regulation of Mitochondrial Function by the Actin Cytoskeleton |
| title_fullStr | Regulation of Mitochondrial Function by the Actin Cytoskeleton |
| title_full_unstemmed | Regulation of Mitochondrial Function by the Actin Cytoskeleton |
| title_short | Regulation of Mitochondrial Function by the Actin Cytoskeleton |
| title_sort | regulation of mitochondrial function by the actin cytoskeleton |
| topic | mitochondria actin cytoskeleton OXPHOS system gelsolin mitochondrial disease |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.795838/full |
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