Ferritin Nanocages for Protein Delivery to Tumor Cells
The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the pos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/4/825 |
| _version_ | 1817986846000414720 |
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| author | Federica Palombarini Elisa Di Fabio Alberto Boffi Alberto Macone Alessandra Bonamore |
| author_facet | Federica Palombarini Elisa Di Fabio Alberto Boffi Alberto Macone Alessandra Bonamore |
| author_sort | Federica Palombarini |
| collection | DOAJ |
| description | The delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the possibility of encapsulating even small proteins with enzymatic or cytotoxic activity is emerging. Among all ferritins, particular interest is paid to the <i>Archaeoglobus fulgidus</i> one, due to its peculiar ability to associate/dissociate in physiological conditions. This protein has also been engineered to allow recognition of human receptors and used in vitro for the delivery of cytotoxic proteins with extremely promising results. |
| first_indexed | 2024-04-14T00:14:28Z |
| format | Article |
| id | doaj.art-ba4f45f26fe14cd6ba757b21cc65216b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-14T00:14:28Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ba4f45f26fe14cd6ba757b21cc65216b2022-12-22T02:23:12ZengMDPI AGMolecules1420-30492020-02-0125482510.3390/molecules25040825molecules25040825Ferritin Nanocages for Protein Delivery to Tumor CellsFederica Palombarini0Elisa Di Fabio1Alberto Boffi2Alberto Macone3Alessandra Bonamore4Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyThe delivery of therapeutic proteins is one of the greatest challenges in the treatment of human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow spherical structure, they are used as modular nanocages for the delivery of anticancer drugs. More recently, the possibility of encapsulating even small proteins with enzymatic or cytotoxic activity is emerging. Among all ferritins, particular interest is paid to the <i>Archaeoglobus fulgidus</i> one, due to its peculiar ability to associate/dissociate in physiological conditions. This protein has also been engineered to allow recognition of human receptors and used in vitro for the delivery of cytotoxic proteins with extremely promising results.https://www.mdpi.com/1420-3049/25/4/825ferritindrug deliverytherapeutic proteinsnanocarrier<i>archaeoglobus fulgidus</i>tfr1 receptortumor cells |
| spellingShingle | Federica Palombarini Elisa Di Fabio Alberto Boffi Alberto Macone Alessandra Bonamore Ferritin Nanocages for Protein Delivery to Tumor Cells Molecules ferritin drug delivery therapeutic proteins nanocarrier <i>archaeoglobus fulgidus</i> tfr1 receptor tumor cells |
| title | Ferritin Nanocages for Protein Delivery to Tumor Cells |
| title_full | Ferritin Nanocages for Protein Delivery to Tumor Cells |
| title_fullStr | Ferritin Nanocages for Protein Delivery to Tumor Cells |
| title_full_unstemmed | Ferritin Nanocages for Protein Delivery to Tumor Cells |
| title_short | Ferritin Nanocages for Protein Delivery to Tumor Cells |
| title_sort | ferritin nanocages for protein delivery to tumor cells |
| topic | ferritin drug delivery therapeutic proteins nanocarrier <i>archaeoglobus fulgidus</i> tfr1 receptor tumor cells |
| url | https://www.mdpi.com/1420-3049/25/4/825 |
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