Effect of Pre-hospital Thrombolysis on Mortality in Patients with Myocardial Infarction: A Systematic Review and Meta-analysis
Background and purpose: Early treatment of thrombolysis can reduce mortality in patients with myocardial infarction, so, this systematic review and meta-analysis aimed to compare the effect of pre-hospital thrombolysis and in-hospital thrombolysis on short-term mortality in patients with myocardial...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2018-09-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-11916-en.html |
| _version_ | 1828054883144564736 |
|---|---|
| author | Majid Saeedi Mahboubeh Eslami Parisa Eslami Maryam Ghajar Arash Akhlaghi Akbar Hedayatizadeh-Omran Reza Alizadeh-Navaei |
| author_facet | Majid Saeedi Mahboubeh Eslami Parisa Eslami Maryam Ghajar Arash Akhlaghi Akbar Hedayatizadeh-Omran Reza Alizadeh-Navaei |
| author_sort | Majid Saeedi |
| collection | DOAJ |
| description | Background and purpose: Early treatment of thrombolysis can reduce mortality in patients with myocardial infarction, so, this systematic review and meta-analysis aimed to compare the effect of pre-hospital thrombolysis and in-hospital thrombolysis on short-term mortality in patients with myocardial infarction.
Materials and methods: Systematic search was conducted in electronic databases including Pubmed, Web of Science, Cochrane, and Embase without time and language constraints using related keywords. All articles were exported to EndNote. In initial search, 223 articles were found but finally 10 articles were selected for quality assessment, which was performed using the JADAD standard checklist for interventional studies and the Newcastle Ottawa Scale checklist for cohort studies. Comprehensive Meta-Analysis software was used for data analysis.
Results: The total samples size was 4291 in the pre-hospital group and 4,730 in the in-hospital group. Three clinical trials and all three cohort studies were found to have a good quality. Meta-analysis showed that thrombolytic therapy at the onset of symptoms and prior to patient's transfer to hospital could reduce mortality by 36% (OR= 0.64 CI 95%: 0.45-0.91).
Conclusion: Pre-hospital thrombolysis by emergency technicians can reduce mortality in patients with myocardial infarction. |
| first_indexed | 2024-04-10T20:29:57Z |
| format | Article |
| id | doaj.art-ba506d962559404180b77d704d64a76c |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:29:57Z |
| publishDate | 2018-09-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-ba506d962559404180b77d704d64a76c2023-01-25T07:29:47ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792018-09-0128164170178Effect of Pre-hospital Thrombolysis on Mortality in Patients with Myocardial Infarction: A Systematic Review and Meta-analysisMajid Saeedi0Mahboubeh Eslami1Parisa Eslami2Maryam Ghajar3Arash Akhlaghi4Akbar Hedayatizadeh-Omran5Reza Alizadeh-Navaei6 Professor, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Pharmaceutical Sciences Research Center, Haemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran MSc in Medical Informatics, Mazandaran University of Medical Sciences, Sari, Iran Community Medicine Specialist, Mazandaran University of Medical Sciences, Sari, Iran MSc in Microbiology, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Cardiologist, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran 7 Assistant Professor, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Early treatment of thrombolysis can reduce mortality in patients with myocardial infarction, so, this systematic review and meta-analysis aimed to compare the effect of pre-hospital thrombolysis and in-hospital thrombolysis on short-term mortality in patients with myocardial infarction. Materials and methods: Systematic search was conducted in electronic databases including Pubmed, Web of Science, Cochrane, and Embase without time and language constraints using related keywords. All articles were exported to EndNote. In initial search, 223 articles were found but finally 10 articles were selected for quality assessment, which was performed using the JADAD standard checklist for interventional studies and the Newcastle Ottawa Scale checklist for cohort studies. Comprehensive Meta-Analysis software was used for data analysis. Results: The total samples size was 4291 in the pre-hospital group and 4,730 in the in-hospital group. Three clinical trials and all three cohort studies were found to have a good quality. Meta-analysis showed that thrombolytic therapy at the onset of symptoms and prior to patient's transfer to hospital could reduce mortality by 36% (OR= 0.64 CI 95%: 0.45-0.91). Conclusion: Pre-hospital thrombolysis by emergency technicians can reduce mortality in patients with myocardial infarction.http://jmums.mazums.ac.ir/article-1-11916-en.htmlthrombolytic therapymortalitymyocardial infarction |
| spellingShingle | Majid Saeedi Mahboubeh Eslami Parisa Eslami Maryam Ghajar Arash Akhlaghi Akbar Hedayatizadeh-Omran Reza Alizadeh-Navaei Effect of Pre-hospital Thrombolysis on Mortality in Patients with Myocardial Infarction: A Systematic Review and Meta-analysis Journal of Mazandaran University of Medical Sciences thrombolytic therapy mortality myocardial infarction |
| title | Effect of Pre-hospital Thrombolysis on Mortality in
Patients with Myocardial Infarction:
A Systematic Review and Meta-analysis |
| title_full | Effect of Pre-hospital Thrombolysis on Mortality in
Patients with Myocardial Infarction:
A Systematic Review and Meta-analysis |
| title_fullStr | Effect of Pre-hospital Thrombolysis on Mortality in
Patients with Myocardial Infarction:
A Systematic Review and Meta-analysis |
| title_full_unstemmed | Effect of Pre-hospital Thrombolysis on Mortality in
Patients with Myocardial Infarction:
A Systematic Review and Meta-analysis |
| title_short | Effect of Pre-hospital Thrombolysis on Mortality in
Patients with Myocardial Infarction:
A Systematic Review and Meta-analysis |
| title_sort | effect of pre hospital thrombolysis on mortality in patients with myocardial infarction a systematic review and meta analysis |
| topic | thrombolytic therapy mortality myocardial infarction |
| url | http://jmums.mazums.ac.ir/article-1-11916-en.html |
| work_keys_str_mv | AT majidsaeedi effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT mahboubeheslami effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT parisaeslami effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT maryamghajar effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT arashakhlaghi effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT akbarhedayatizadehomran effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis AT rezaalizadehnavaei effectofprehospitalthrombolysisonmortalityinpatientswithmyocardialinfarctionasystematicreviewandmetaanalysis |