Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families

Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families

ABSTRACT Repetitive elements cause assembly fragmentation in complex eukaryotic genomes, limiting the study of their variability. The genome of Trypanosoma cruzi, the parasite that causes Chagas disease, has a high repetitive content, including multigene families. Although many T. cruzi multigene fa...

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Bibliographic Details
Main Authors: João Luís Reis-Cunha, Anderson Coqueiro-dos-Santos, Samuel Alexandre Pimenta-Carvalho, Larissa Pinheiro Marques, Gabriela F. Rodrigues-Luiz, Rodrigo P. Baptista, Laila Viana de Almeida, Nathan Ravi Medeiros Honorato, Francisco Pereira Lobo, Vanessa Gomes Fraga, Lucia Maria da Cunha Galvão, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Mariana Santos Cardoso, Gustavo Coutinho Cerqueira, Daniella C. Bartholomeu
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
multicopy genes
variability
copy number variation
complex genomes
T. cruzi
MASP
Online Access:https://journals.asm.org/doi/10.1128/mbio.02319-22

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