Nanomedicine Strategies for Targeting Tumor Stroma
The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of vario...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/16/4145 |
| _version_ | 1797585270972874752 |
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| author | Mei-Chi Su Susheel Kumar Nethi Pavan Kumar Dhanyamraju Swayam Prabha |
| author_facet | Mei-Chi Su Susheel Kumar Nethi Pavan Kumar Dhanyamraju Swayam Prabha |
| author_sort | Mei-Chi Su |
| collection | DOAJ |
| description | The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies. |
| first_indexed | 2024-03-11T00:03:40Z |
| format | Article |
| id | doaj.art-ba51c9e2cc714f9dbb9ed10f724bb36b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:03:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ba51c9e2cc714f9dbb9ed10f724bb36b2023-11-19T00:33:55ZengMDPI AGCancers2072-66942023-08-011516414510.3390/cancers15164145Nanomedicine Strategies for Targeting Tumor StromaMei-Chi Su0Susheel Kumar Nethi1Pavan Kumar Dhanyamraju2Swayam Prabha3Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USANanovaccine Institute, Department of Chemical & Biological Engineering, Iowa State University, Ames, IA 50011, USAFels Cancer Institute of Personalized Medicine, Lewis-Katz School of Medicine, Temple University, Philadelphia, PA 19140, USAFels Cancer Institute of Personalized Medicine, Lewis-Katz School of Medicine, Temple University, Philadelphia, PA 19140, USAThe tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies.https://www.mdpi.com/2072-6694/15/16/4145tumor microenvironmentextracellular matrixcollagenfibronectinhyaluronic acidcancer-associated fibroblasts |
| spellingShingle | Mei-Chi Su Susheel Kumar Nethi Pavan Kumar Dhanyamraju Swayam Prabha Nanomedicine Strategies for Targeting Tumor Stroma Cancers tumor microenvironment extracellular matrix collagen fibronectin hyaluronic acid cancer-associated fibroblasts |
| title | Nanomedicine Strategies for Targeting Tumor Stroma |
| title_full | Nanomedicine Strategies for Targeting Tumor Stroma |
| title_fullStr | Nanomedicine Strategies for Targeting Tumor Stroma |
| title_full_unstemmed | Nanomedicine Strategies for Targeting Tumor Stroma |
| title_short | Nanomedicine Strategies for Targeting Tumor Stroma |
| title_sort | nanomedicine strategies for targeting tumor stroma |
| topic | tumor microenvironment extracellular matrix collagen fibronectin hyaluronic acid cancer-associated fibroblasts |
| url | https://www.mdpi.com/2072-6694/15/16/4145 |
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