A Review on Chitosan and Cellulose Hydrogels for Wound Dressings
Wound management remains a challenging issue around the world, although a lot of wound dressing materials have been produced for the treatment of chronic and acute wounds. Wound healing is a highly dynamic and complex regulatory process that involves four principal integrated phases, including hemos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/23/5163 |
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| author | Collins N. Elangwe Svetlana N. Morozkina Roman O. Olekhnovich Alexander Krasichkov Victoriya O. Polyakova Mayya V. Uspenskaya |
| author_facet | Collins N. Elangwe Svetlana N. Morozkina Roman O. Olekhnovich Alexander Krasichkov Victoriya O. Polyakova Mayya V. Uspenskaya |
| author_sort | Collins N. Elangwe |
| collection | DOAJ |
| description | Wound management remains a challenging issue around the world, although a lot of wound dressing materials have been produced for the treatment of chronic and acute wounds. Wound healing is a highly dynamic and complex regulatory process that involves four principal integrated phases, including hemostasis, inflammation, proliferation, and remodeling. Chronic non-healing wounds are wounds that heal significantly more slowly, fail to progress to all the phases of the normal wound healing process, and are usually stalled at the inflammatory phase. These wounds cause a lot of challenges to patients, such as severe emotional and physical stress and generate a considerable financial burden on patients and the general public healthcare system. It has been reported that about 1–2% of the global population suffers from chronic non-healing wounds during their lifetime in developed nations. Traditional wound dressings are dry, and therefore cannot provide moist environment for wound healing and do not possess antibacterial properties. Wound dressings that are currently used consist of bandages, films, foams, patches and hydrogels. Currently, hydrogels are gaining much attention as a result of their water-holding capacity, providing a moist wound-healing milieu. Chitosan is a biopolymer that has gained a lot of attention recently in the pharmaceutical industry due to its unique chemical and antibacterial nature. However, with its poor mechanical properties, chitosan is incorporated with other biopolymers, such as the cellulose of desirable biocompatibility, at the same time having the improved mechanical and physical properties of the hydrogels. This review focuses on the study of biopolymers, such as cellulose and chitosan hydrogels, for wound treatment. |
| first_indexed | 2024-03-09T17:35:05Z |
| format | Article |
| id | doaj.art-ba5210e8497c477fbfa1cc9a5e00d791 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T17:35:05Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ba5210e8497c477fbfa1cc9a5e00d7912023-11-24T11:59:27ZengMDPI AGPolymers2073-43602022-11-011423516310.3390/polym14235163A Review on Chitosan and Cellulose Hydrogels for Wound DressingsCollins N. Elangwe0Svetlana N. Morozkina1Roman O. Olekhnovich2Alexander Krasichkov3Victoriya O. Polyakova4Mayya V. Uspenskaya5Chemical Engineering Center, ITMO University, Kronverkskiy Prospect, 49A, Saint Petersburg 197101, RussiaChemical Engineering Center, ITMO University, Kronverkskiy Prospect, 49A, Saint Petersburg 197101, RussiaChemical Engineering Center, ITMO University, Kronverkskiy Prospect, 49A, Saint Petersburg 197101, RussiaDepartments of Radio Engineering Systems, Electrotechnical University “LETI”, Prof. Popova Street 5F, Saint Petersburg 197022, RussiaSt. Petersburg Research Institute of Phthisiopulmonology, Ligovsky 2-4, Saint Petersburg 191036, RussiaChemical Engineering Center, ITMO University, Kronverkskiy Prospect, 49A, Saint Petersburg 197101, RussiaWound management remains a challenging issue around the world, although a lot of wound dressing materials have been produced for the treatment of chronic and acute wounds. Wound healing is a highly dynamic and complex regulatory process that involves four principal integrated phases, including hemostasis, inflammation, proliferation, and remodeling. Chronic non-healing wounds are wounds that heal significantly more slowly, fail to progress to all the phases of the normal wound healing process, and are usually stalled at the inflammatory phase. These wounds cause a lot of challenges to patients, such as severe emotional and physical stress and generate a considerable financial burden on patients and the general public healthcare system. It has been reported that about 1–2% of the global population suffers from chronic non-healing wounds during their lifetime in developed nations. Traditional wound dressings are dry, and therefore cannot provide moist environment for wound healing and do not possess antibacterial properties. Wound dressings that are currently used consist of bandages, films, foams, patches and hydrogels. Currently, hydrogels are gaining much attention as a result of their water-holding capacity, providing a moist wound-healing milieu. Chitosan is a biopolymer that has gained a lot of attention recently in the pharmaceutical industry due to its unique chemical and antibacterial nature. However, with its poor mechanical properties, chitosan is incorporated with other biopolymers, such as the cellulose of desirable biocompatibility, at the same time having the improved mechanical and physical properties of the hydrogels. This review focuses on the study of biopolymers, such as cellulose and chitosan hydrogels, for wound treatment.https://www.mdpi.com/2073-4360/14/23/5163chitosancellulose nanocrystalshydrogelswound dressingchronic woundsmarket products |
| spellingShingle | Collins N. Elangwe Svetlana N. Morozkina Roman O. Olekhnovich Alexander Krasichkov Victoriya O. Polyakova Mayya V. Uspenskaya A Review on Chitosan and Cellulose Hydrogels for Wound Dressings Polymers chitosan cellulose nanocrystals hydrogels wound dressing chronic wounds market products |
| title | A Review on Chitosan and Cellulose Hydrogels for Wound Dressings |
| title_full | A Review on Chitosan and Cellulose Hydrogels for Wound Dressings |
| title_fullStr | A Review on Chitosan and Cellulose Hydrogels for Wound Dressings |
| title_full_unstemmed | A Review on Chitosan and Cellulose Hydrogels for Wound Dressings |
| title_short | A Review on Chitosan and Cellulose Hydrogels for Wound Dressings |
| title_sort | review on chitosan and cellulose hydrogels for wound dressings |
| topic | chitosan cellulose nanocrystals hydrogels wound dressing chronic wounds market products |
| url | https://www.mdpi.com/2073-4360/14/23/5163 |
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