Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits
Background and aims: Wound healing is one of the most important issues in medical science. Synthetic drugs have long been introduced and used to speed up the healing process of wounds, but most of them have many side effects. The present study was performed to evaluate the healing efficiency of wate...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2023-05-01
|
| Series: | Journal of Shahrekord University of Medical Sciences |
| Subjects: | |
| Online Access: | https://j.skums.ac.ir/PDF/jskums-25-115.pdf |
| _version_ | 1797738751545311232 |
|---|---|
| author | Faezeh Dehestani Ardakani Elham Salehi Majid Morovati-Sharifabad Amin Paidar Ardakani Mohammad Saeed Heydarnejad |
| author_facet | Faezeh Dehestani Ardakani Elham Salehi Majid Morovati-Sharifabad Amin Paidar Ardakani Mohammad Saeed Heydarnejad |
| author_sort | Faezeh Dehestani Ardakani |
| collection | DOAJ |
| description | Background and aims: Wound healing is one of the most important issues in medical science. Synthetic drugs have long been introduced and used to speed up the healing process of wounds, but most of them have many side effects. The present study was performed to evaluate the healing efficiency of watercress seed mucilage (Lepidium sativum L.) on wounds. Methods: In this study, the animals were randomly divided into five groups. The treatment groups were (1), (2), (3), sham (4), and control (5). The treatment groups were treated with 20%, 10%, and 5% watercress seed mucilage in the Eucerin base, respectively, and the sham was treated with Eucerin, while the control received no treatment. Then, 5 pairs of full-thickness wounds with a diameter of 7 mm were created on both sides of the rabbit’s spine. Macroscopic and wound area studies were performed on days 4, 7, and 14 after surgery. Results: According to the analysis of variance, there was a significant difference between groups 1, 2, 3, sham, and control (P=0.001), but no significant difference was observed between group 3, sham group, and control group (P=0.993). Based on these findings, at the end of the treatment period, group 1 had the highest healing rate and the lowest wound area (1.12±0.77) compared to group 2 (4.42±0.30) and 3 (7.05±0.35), as well as the sham (8.34±1.10) and control (8.50±1.90) groups. Thus, the treatment method of this group has been more effective in wound healing than that of the other treatment groups. Conclusion: It seems that watercress seed mucilage can treat wounds due to its important compounds such as flavonoids, phenols, and vitamins A and C. |
| first_indexed | 2024-03-12T13:48:23Z |
| format | Article |
| id | doaj.art-ba521a4302264a9a82b1faeacf525678 |
| institution | Directory Open Access Journal |
| issn | 2717-0071 |
| language | English |
| last_indexed | 2024-03-12T13:48:23Z |
| publishDate | 2023-05-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of Shahrekord University of Medical Sciences |
| spelling | doaj.art-ba521a4302264a9a82b1faeacf5256782023-08-23T08:08:55ZengShahrekord University of Medical SciencesJournal of Shahrekord University of Medical Sciences2717-00712023-05-0125311512310.34172/jsums.2023.681jskums-681Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbitsFaezeh Dehestani Ardakani0Elham Salehi1Majid Morovati-Sharifabad2Amin Paidar Ardakani3Mohammad Saeed Heydarnejad4Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, IranDepartment of Animal Sciences, Faculty of Basic Sciences, Shahrekord University, Shahrekord, IranBackground and aims: Wound healing is one of the most important issues in medical science. Synthetic drugs have long been introduced and used to speed up the healing process of wounds, but most of them have many side effects. The present study was performed to evaluate the healing efficiency of watercress seed mucilage (Lepidium sativum L.) on wounds. Methods: In this study, the animals were randomly divided into five groups. The treatment groups were (1), (2), (3), sham (4), and control (5). The treatment groups were treated with 20%, 10%, and 5% watercress seed mucilage in the Eucerin base, respectively, and the sham was treated with Eucerin, while the control received no treatment. Then, 5 pairs of full-thickness wounds with a diameter of 7 mm were created on both sides of the rabbit’s spine. Macroscopic and wound area studies were performed on days 4, 7, and 14 after surgery. Results: According to the analysis of variance, there was a significant difference between groups 1, 2, 3, sham, and control (P=0.001), but no significant difference was observed between group 3, sham group, and control group (P=0.993). Based on these findings, at the end of the treatment period, group 1 had the highest healing rate and the lowest wound area (1.12±0.77) compared to group 2 (4.42±0.30) and 3 (7.05±0.35), as well as the sham (8.34±1.10) and control (8.50±1.90) groups. Thus, the treatment method of this group has been more effective in wound healing than that of the other treatment groups. Conclusion: It seems that watercress seed mucilage can treat wounds due to its important compounds such as flavonoids, phenols, and vitamins A and C.https://j.skums.ac.ir/PDF/jskums-25-115.pdfmucilagelepidum sativum seedwound healingsurgery |
| spellingShingle | Faezeh Dehestani Ardakani Elham Salehi Majid Morovati-Sharifabad Amin Paidar Ardakani Mohammad Saeed Heydarnejad Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits Journal of Shahrekord University of Medical Sciences mucilage lepidum sativum seed wound healing surgery |
| title | Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits |
| title_full | Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits |
| title_fullStr | Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits |
| title_full_unstemmed | Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits |
| title_short | Effect of watercress seed mucilage (Lepidium sativum L.) on the wound healing in New Zealand rabbits |
| title_sort | effect of watercress seed mucilage lepidium sativum l on the wound healing in new zealand rabbits |
| topic | mucilage lepidum sativum seed wound healing surgery |
| url | https://j.skums.ac.ir/PDF/jskums-25-115.pdf |
| work_keys_str_mv | AT faezehdehestaniardakani effectofwatercressseedmucilagelepidiumsativumlonthewoundhealinginnewzealandrabbits AT elhamsalehi effectofwatercressseedmucilagelepidiumsativumlonthewoundhealinginnewzealandrabbits AT majidmorovatisharifabad effectofwatercressseedmucilagelepidiumsativumlonthewoundhealinginnewzealandrabbits AT aminpaidarardakani effectofwatercressseedmucilagelepidiumsativumlonthewoundhealinginnewzealandrabbits AT mohammadsaeedheydarnejad effectofwatercressseedmucilagelepidiumsativumlonthewoundhealinginnewzealandrabbits |