Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice
Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice. P enhanced spermatozoal hyperactivation and increased IVF success...
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| Format: | Article |
| Language: | English |
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The Society for Reproduction and Development
2023-03-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/69/3/69_2022-114/_pdf/-char/en |
| _version_ | 1797633959889207296 |
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| author | Risa SUZUKI Masakatsu FUJINOKI |
| author_facet | Risa SUZUKI Masakatsu FUJINOKI |
| author_sort | Risa SUZUKI |
| collection | DOAJ |
| description | Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice. P enhanced spermatozoal hyperactivation and increased IVF success rate in a dose-dependent manner. Moreover, P affected spermatozoal hyperactivation and IVF through the membrane progesterone receptor of the spermatozoal head. These results show that P regulates spermatozoal capacitation and fertilization in mice. The concentration of P changes during the estrous cycle, indicating that spermatozoa are capacitated in response to the oviductal environment and subsequently fertilize the oocyte. |
| first_indexed | 2024-03-11T12:01:58Z |
| format | Article |
| id | doaj.art-ba53d6ba22a8413fa6b161a1fa8ea036 |
| institution | Directory Open Access Journal |
| issn | 0916-8818 1348-4400 |
| language | English |
| last_indexed | 2024-03-11T12:01:58Z |
| publishDate | 2023-03-01 |
| publisher | The Society for Reproduction and Development |
| record_format | Article |
| series | The Journal of Reproduction and Development |
| spelling | doaj.art-ba53d6ba22a8413fa6b161a1fa8ea0362023-11-08T04:43:38ZengThe Society for Reproduction and DevelopmentThe Journal of Reproduction and Development0916-88181348-44002023-03-0169314715310.1262/jrd.2022-114jrdProgesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in miceRisa SUZUKI0Masakatsu FUJINOKI1Research Lab. of Laboratory Animals, Research Center for Laboratory Animals, Comprehensive Research Facilities for Advanced Medical Science, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, JapanResearch Lab. of Laboratory Animals, Research Center for Laboratory Animals, Comprehensive Research Facilities for Advanced Medical Science, School of Medicine, Dokkyo Medical University, Tochigi 321-0293, JapanProgesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice. P enhanced spermatozoal hyperactivation and increased IVF success rate in a dose-dependent manner. Moreover, P affected spermatozoal hyperactivation and IVF through the membrane progesterone receptor of the spermatozoal head. These results show that P regulates spermatozoal capacitation and fertilization in mice. The concentration of P changes during the estrous cycle, indicating that spermatozoa are capacitated in response to the oviductal environment and subsequently fertilize the oocyte.https://www.jstage.jst.go.jp/article/jrd/69/3/69_2022-114/_pdf/-char/encapacitationhyperactivationin vitro fertilizationprogesteronespermatozoon |
| spellingShingle | Risa SUZUKI Masakatsu FUJINOKI Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice The Journal of Reproduction and Development capacitation hyperactivation in vitro fertilization progesterone spermatozoon |
| title | Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| title_full | Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| title_fullStr | Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| title_full_unstemmed | Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| title_short | Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| title_sort | progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice |
| topic | capacitation hyperactivation in vitro fertilization progesterone spermatozoon |
| url | https://www.jstage.jst.go.jp/article/jrd/69/3/69_2022-114/_pdf/-char/en |
| work_keys_str_mv | AT risasuzuki progesteroneincreasesthesuccessofinvitrofertilizationviaenhancedspermhyperactivationinmice AT masakatsufujinoki progesteroneincreasesthesuccessofinvitrofertilizationviaenhancedspermhyperactivationinmice |