Role of MCP-1 as an inflammatory biomarker in nephropathy
The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303076/full |
| _version_ | 1827391195006894080 |
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| author | Yanlong Liu Ke Xu Yuhua Xiang Boyan Ma Hailong Li Yuan Li Yue Shi Shuju Li Yan Bai |
| author_facet | Yanlong Liu Ke Xu Yuhua Xiang Boyan Ma Hailong Li Yuan Li Yue Shi Shuju Li Yan Bai |
| author_sort | Yanlong Liu |
| collection | DOAJ |
| description | The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding to its receptor, MCP-1 can induce lymphocytes and NK cells’ homing, migration, activation, differentiation, and development while promoting monocytes’ and macrophages’ infiltration, thereby facilitating kidney disease-related inflammation. As a biomarker for kidney disease, MCP-1 has made notable advancements in primary kidney diseases such as crescentic glomerulonephritis, chronic glomerulonephritis, primary glomerulopathy, idiopathic proteinuria glomerulopathy, acute kidney injury; secondary kidney diseases like diabetic nephropathy and lupus nephritis; hereditary kidney diseases including autosomal dominant polycystic kidney disease and sickle cell kidney disease. MCP-1 not only predicts the occurrence, progression, prognosis of the disease but is also closely associated with the severity and stage of nephropathy. When renal tissue is stimulated or experiences significant damage, the expression of MCP-1 increases, demonstrating a direct correlation with the severity of renal injury. |
| first_indexed | 2024-03-08T17:06:12Z |
| format | Article |
| id | doaj.art-ba5441b03fce4a75b8c49406798d1b63 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T17:06:12Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ba5441b03fce4a75b8c49406798d1b632024-01-04T04:47:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13030761303076Role of MCP-1 as an inflammatory biomarker in nephropathyYanlong Liu0Ke Xu1Yuhua Xiang2Boyan Ma3Hailong Li4Yuan Li5Yue Shi6Shuju Li7Yan Bai8Heilongjiang Provincial Health Commission, Harbin, ChinaHeilongjiang University of Chinese Medicine, The Second Clinical Medical College, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaHeilongjiang University of Chinese Medicine, The Second Clinical Medical College, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaThe First Affiliated Hospital of Harbin Medical University, Harbin, ChinaHeilongjiang University of Chinese Medicine, The Second Clinical Medical College, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaHeilongjiang Academy of Traditional Chinese Medicine, Harbin, ChinaThe Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding to its receptor, MCP-1 can induce lymphocytes and NK cells’ homing, migration, activation, differentiation, and development while promoting monocytes’ and macrophages’ infiltration, thereby facilitating kidney disease-related inflammation. As a biomarker for kidney disease, MCP-1 has made notable advancements in primary kidney diseases such as crescentic glomerulonephritis, chronic glomerulonephritis, primary glomerulopathy, idiopathic proteinuria glomerulopathy, acute kidney injury; secondary kidney diseases like diabetic nephropathy and lupus nephritis; hereditary kidney diseases including autosomal dominant polycystic kidney disease and sickle cell kidney disease. MCP-1 not only predicts the occurrence, progression, prognosis of the disease but is also closely associated with the severity and stage of nephropathy. When renal tissue is stimulated or experiences significant damage, the expression of MCP-1 increases, demonstrating a direct correlation with the severity of renal injury.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303076/fullMCP-1inflammatory markersprimary nephropathysecondary nephropathyhereditary nephropathy |
| spellingShingle | Yanlong Liu Ke Xu Yuhua Xiang Boyan Ma Hailong Li Yuan Li Yue Shi Shuju Li Yan Bai Role of MCP-1 as an inflammatory biomarker in nephropathy Frontiers in Immunology MCP-1 inflammatory markers primary nephropathy secondary nephropathy hereditary nephropathy |
| title | Role of MCP-1 as an inflammatory biomarker in nephropathy |
| title_full | Role of MCP-1 as an inflammatory biomarker in nephropathy |
| title_fullStr | Role of MCP-1 as an inflammatory biomarker in nephropathy |
| title_full_unstemmed | Role of MCP-1 as an inflammatory biomarker in nephropathy |
| title_short | Role of MCP-1 as an inflammatory biomarker in nephropathy |
| title_sort | role of mcp 1 as an inflammatory biomarker in nephropathy |
| topic | MCP-1 inflammatory markers primary nephropathy secondary nephropathy hereditary nephropathy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303076/full |
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