New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications
Arthropod-borne viruses (arboviruses) such as dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and yellow fever virus (YFV) are the most important ‘emerging pathogens’ because of their geographic spread and their increasing impact on vulnerable human populations. To fight against t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-08-01
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| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2414-6366/3/3/80 |
| _version_ | 1818008382583341056 |
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| author | André B. Sagna Mabo C. Yobo Emmanuel Elanga Ndille Franck Remoue |
| author_facet | André B. Sagna Mabo C. Yobo Emmanuel Elanga Ndille Franck Remoue |
| author_sort | André B. Sagna |
| collection | DOAJ |
| description | Arthropod-borne viruses (arboviruses) such as dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and yellow fever virus (YFV) are the most important ‘emerging pathogens’ because of their geographic spread and their increasing impact on vulnerable human populations. To fight against these arboviruses, vector control strategies (VCS) remain one of the most valuable means. However, their implementation and monitoring are labour intensive and difficult to sustain on large scales, especially when transmission and Aedes mosquito densities are low. To increase the efficacy of VCS, current entomological methods should be improved by new complementary tools which measure the risk of arthropod-borne diseases’ transmission. The study of human–Aedes immunological relationships can provide new promising serological tools, namely antibody-based biomarkers, allowing to accurately estimate the human–Aedes contact and consequently, the risk of transmission of arboviruses and the effectiveness of VCS. This review focuses on studies highlighting the concept, techniques, and methods used to develop and validate specific candidate biomarkers of human exposure to Aedes bites. Potential applications of such antibody-based biomarkers of exposure to Aedes vector bites in the field of operational research are also discussed. |
| first_indexed | 2024-04-14T05:28:34Z |
| format | Article |
| id | doaj.art-ba5639b76a8b4fae8a89e10a75db81ad |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-04-14T05:28:34Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-ba5639b76a8b4fae8a89e10a75db81ad2022-12-22T02:09:53ZengMDPI AGTropical Medicine and Infectious Disease2414-63662018-08-01338010.3390/tropicalmed3030080tropicalmed3030080New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to ApplicationsAndré B. Sagna0Mabo C. Yobo1Emmanuel Elanga Ndille2Franck Remoue3MIVEGEC, IRD, CNRS, Univ. Montpellier, BP 64501, 34394 Montpellier, FranceInstitut Pierre Richet (IPR), Institut Nationale de la Santé Publique (INSP), BP 1500 Bouaké, Côte d’IvoireMIVEGEC, IRD, CNRS, Univ. Montpellier, BP 64501, 34394 Montpellier, FranceMIVEGEC, IRD, CNRS, Univ. Montpellier, BP 64501, 34394 Montpellier, FranceArthropod-borne viruses (arboviruses) such as dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), and yellow fever virus (YFV) are the most important ‘emerging pathogens’ because of their geographic spread and their increasing impact on vulnerable human populations. To fight against these arboviruses, vector control strategies (VCS) remain one of the most valuable means. However, their implementation and monitoring are labour intensive and difficult to sustain on large scales, especially when transmission and Aedes mosquito densities are low. To increase the efficacy of VCS, current entomological methods should be improved by new complementary tools which measure the risk of arthropod-borne diseases’ transmission. The study of human–Aedes immunological relationships can provide new promising serological tools, namely antibody-based biomarkers, allowing to accurately estimate the human–Aedes contact and consequently, the risk of transmission of arboviruses and the effectiveness of VCS. This review focuses on studies highlighting the concept, techniques, and methods used to develop and validate specific candidate biomarkers of human exposure to Aedes bites. Potential applications of such antibody-based biomarkers of exposure to Aedes vector bites in the field of operational research are also discussed.http://www.mdpi.com/2414-6366/3/3/80Aedes exposurebiomarkerarbovirus transmissionsalivary proteinsimmuno-epidemiology |
| spellingShingle | André B. Sagna Mabo C. Yobo Emmanuel Elanga Ndille Franck Remoue New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications Tropical Medicine and Infectious Disease Aedes exposure biomarker arbovirus transmission salivary proteins immuno-epidemiology |
| title | New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications |
| title_full | New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications |
| title_fullStr | New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications |
| title_full_unstemmed | New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications |
| title_short | New Immuno-Epidemiological Biomarker of Human Exposure to Aedes Vector Bites: From Concept to Applications |
| title_sort | new immuno epidemiological biomarker of human exposure to aedes vector bites from concept to applications |
| topic | Aedes exposure biomarker arbovirus transmission salivary proteins immuno-epidemiology |
| url | http://www.mdpi.com/2414-6366/3/3/80 |
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