Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population
Abstract Background The triglyceride and glucose (TyG) index, a simple surrogate marker of insulin resistance, is related to cardiovascular disease. However, there is a lack of evidence for the relationship between the TyG index and chest pain. This study aimed to investigate the association of the...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-024-02209-y |
| _version_ | 1797233849292292096 |
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| author | Yao Zhao Yu Gu Bili Zhang |
| author_facet | Yao Zhao Yu Gu Bili Zhang |
| author_sort | Yao Zhao |
| collection | DOAJ |
| description | Abstract Background The triglyceride and glucose (TyG) index, a simple surrogate marker of insulin resistance, is related to cardiovascular disease. However, there is a lack of evidence for the relationship between the TyG index and chest pain. This study aimed to investigate the association of the TyG index with chest pain and to evaluate the relationship between the TyG index and all-cause mortality in participants with or without chest pain. Methods The present study utilized data from the 2001–2012 National Health and Nutrition Examination Survey (NHANES), employing a combination of cross-sectional and cohort study designs. The association between the TyG index and chest pain was investigated using weighted logistic regression models. Weighted Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for all-cause mortality. Restricted cubic spline analysis was used to explore linear or nonlinear relationships between the TyG index and chest pain or all-cause mortality. Results The findings revealed a positive correlation between the TyG index and chest pain, even after adjusting for potential confounding factors (quartile 4 versus quartile 1, odds ratio [OR] 1.42, 95% confidence interval [CI] 1.14–1.77, P = 0.002). During a mean follow-up time of 139 months, a total of 2286 individuals (27.43%) experienced mortality. Weighted multivariate Cox regression models indicated that for each one-unit increase in the TyG index, the adjusted hazard ratio (HR) for mortality was 1.14 (95% CI = 0.94–1.37) for participants with chest pain and 1.25 (95% CI = 1.09–1.43) for those without chest pain. Furthermore, restricted cubic spline analysis revealed a linear relationship between the TyG index and chest pain (P for nonlinearity = 0.902), whereas a nonlinear relationship was shown between the TyG index and all-cause mortality among populations regardless of chest pain (all P for nonlinearity < 0.01). Conclusion The TyG index was positively linked to a higher incidence of chest pain. Moreover, the TyG index was associated with all-cause mortality not only in participants with chest pain but also in those without chest pain. |
| first_indexed | 2024-04-24T16:22:42Z |
| format | Article |
| id | doaj.art-ba56becd6aef4622bf6023ac9a1b4276 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-24T16:22:42Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ba56becd6aef4622bf6023ac9a1b42762024-03-31T11:10:04ZengBMCCardiovascular Diabetology1475-28402024-03-0123111110.1186/s12933-024-02209-yAssociations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. populationYao Zhao0Yu Gu1Bili Zhang2Department of Cardiovascular Surgery, Changhai Hospital, Naval Military Medical UniversityDepartment of Neonatology, Women’s Hospital, Zhejiang University School of MedicineDepartment of Cardiovasology, Changhai Hospital, Naval Military Medical UniversityAbstract Background The triglyceride and glucose (TyG) index, a simple surrogate marker of insulin resistance, is related to cardiovascular disease. However, there is a lack of evidence for the relationship between the TyG index and chest pain. This study aimed to investigate the association of the TyG index with chest pain and to evaluate the relationship between the TyG index and all-cause mortality in participants with or without chest pain. Methods The present study utilized data from the 2001–2012 National Health and Nutrition Examination Survey (NHANES), employing a combination of cross-sectional and cohort study designs. The association between the TyG index and chest pain was investigated using weighted logistic regression models. Weighted Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for all-cause mortality. Restricted cubic spline analysis was used to explore linear or nonlinear relationships between the TyG index and chest pain or all-cause mortality. Results The findings revealed a positive correlation between the TyG index and chest pain, even after adjusting for potential confounding factors (quartile 4 versus quartile 1, odds ratio [OR] 1.42, 95% confidence interval [CI] 1.14–1.77, P = 0.002). During a mean follow-up time of 139 months, a total of 2286 individuals (27.43%) experienced mortality. Weighted multivariate Cox regression models indicated that for each one-unit increase in the TyG index, the adjusted hazard ratio (HR) for mortality was 1.14 (95% CI = 0.94–1.37) for participants with chest pain and 1.25 (95% CI = 1.09–1.43) for those without chest pain. Furthermore, restricted cubic spline analysis revealed a linear relationship between the TyG index and chest pain (P for nonlinearity = 0.902), whereas a nonlinear relationship was shown between the TyG index and all-cause mortality among populations regardless of chest pain (all P for nonlinearity < 0.01). Conclusion The TyG index was positively linked to a higher incidence of chest pain. Moreover, the TyG index was associated with all-cause mortality not only in participants with chest pain but also in those without chest pain.https://doi.org/10.1186/s12933-024-02209-yTriglyceride-glucose indexInsulin resistanceChest painNHANESMortality |
| spellingShingle | Yao Zhao Yu Gu Bili Zhang Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population Cardiovascular Diabetology Triglyceride-glucose index Insulin resistance Chest pain NHANES Mortality |
| title | Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population |
| title_full | Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population |
| title_fullStr | Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population |
| title_full_unstemmed | Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population |
| title_short | Associations of triglyceride-glucose (TyG) index with chest pain incidence and mortality among the U.S. population |
| title_sort | associations of triglyceride glucose tyg index with chest pain incidence and mortality among the u s population |
| topic | Triglyceride-glucose index Insulin resistance Chest pain NHANES Mortality |
| url | https://doi.org/10.1186/s12933-024-02209-y |
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