Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial
The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion...
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MDPI AG
2022-02-01
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| Online Access: | https://www.mdpi.com/2076-3417/12/4/1973 |
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| author | Amanda Cristine de Oliveira Anna Paula Oliveira Gomes Lorena Charife Rodrigues Raisa da Silva Cunha Thaís Martins Serra Raquel Machado Schincaglia Marina Alves Coelho Silva Maria Aderuza Horst Maurício Ariel Rostagno Kelly Grace Magalhães Luiz Carlos Cunha Patrícia Borges Botelho |
| author_facet | Amanda Cristine de Oliveira Anna Paula Oliveira Gomes Lorena Charife Rodrigues Raisa da Silva Cunha Thaís Martins Serra Raquel Machado Schincaglia Marina Alves Coelho Silva Maria Aderuza Horst Maurício Ariel Rostagno Kelly Grace Magalhães Luiz Carlos Cunha Patrícia Borges Botelho |
| author_sort | Amanda Cristine de Oliveira |
| collection | DOAJ |
| description | The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion of an organic BLS juice containing different concentrations of polyphenols modulated some biomarkers of oxidative stress after the ingestion of a high-fat meal in individuals with dyslipidemia. A controlled, randomized, double-blind, crossover clinical trial with a washout period of 1 week was carried out. A 12-h fasting blood sample was collected. Afterward, the participants consumed a high-fat meal, followed by the ingestion of a placebo or one of the organic BLS juices containing either 32.0 or 77.5 mg/100 mL of polyphenols. Blood samples were obtained 30, 60, 120 and 180 min after the first blood collection. The composition analysis showed that organic BLS had a better nutritional composition than conventional ones. The high-fat meal induced postprandial hypertriglyceridemia after 120 min (<i>p</i> < 0.001) and increased the concentration of malondialdehyde after 30 min (<i>p</i> < 0.001). In addition, there was a significant increase in GPx in 30 min (<i>p</i> = 0.026). This increase was attenuated in the group that received the highest dose of polyphenols when compared with the placebo after 30 min (<i>p</i> = 0.045). Therefore, the organic BLS juice containing 77.5 mg of polyphenols was efficient at modulating one of the postprandial mechanisms of enzymatic antioxidant protection in individuals with dyslipidemia. |
| first_indexed | 2024-03-09T22:41:55Z |
| format | Article |
| id | doaj.art-ba5b40a5a3ca405fa3c359008c96fa24 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T22:41:55Z |
| publishDate | 2022-02-01 |
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| series | Applied Sciences |
| spelling | doaj.art-ba5b40a5a3ca405fa3c359008c96fa242023-11-23T18:37:10ZengMDPI AGApplied Sciences2076-34172022-02-01124197310.3390/app12041973Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled TrialAmanda Cristine de Oliveira0Anna Paula Oliveira Gomes1Lorena Charife Rodrigues2Raisa da Silva Cunha3Thaís Martins Serra4Raquel Machado Schincaglia5Marina Alves Coelho Silva6Maria Aderuza Horst7Maurício Ariel Rostagno8Kelly Grace Magalhães9Luiz Carlos Cunha10Patrícia Borges Botelho11College of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Pharmacy, Federal University of Goias, Goiânia 74605-170, BrazilCollege of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilCollege of Applied Sciences, State University of Campinas, Limeira 13484-350, BrazilLaboratory of Immunology and Inflammation, University of Brasília, Brasília 70910-900, BrazilCollege of Pharmacy, Federal University of Goias, Goiânia 74605-170, BrazilDepartment of Nutrition, College of Health Sciences, University of Brasília, Brasília 70910-900, BrazilThe beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the organic and conventional BLS and to verify whether the ingestion of an organic BLS juice containing different concentrations of polyphenols modulated some biomarkers of oxidative stress after the ingestion of a high-fat meal in individuals with dyslipidemia. A controlled, randomized, double-blind, crossover clinical trial with a washout period of 1 week was carried out. A 12-h fasting blood sample was collected. Afterward, the participants consumed a high-fat meal, followed by the ingestion of a placebo or one of the organic BLS juices containing either 32.0 or 77.5 mg/100 mL of polyphenols. Blood samples were obtained 30, 60, 120 and 180 min after the first blood collection. The composition analysis showed that organic BLS had a better nutritional composition than conventional ones. The high-fat meal induced postprandial hypertriglyceridemia after 120 min (<i>p</i> < 0.001) and increased the concentration of malondialdehyde after 30 min (<i>p</i> < 0.001). In addition, there was a significant increase in GPx in 30 min (<i>p</i> = 0.026). This increase was attenuated in the group that received the highest dose of polyphenols when compared with the placebo after 30 min (<i>p</i> = 0.045). Therefore, the organic BLS juice containing 77.5 mg of polyphenols was efficient at modulating one of the postprandial mechanisms of enzymatic antioxidant protection in individuals with dyslipidemia.https://www.mdpi.com/2076-3417/12/4/1973antioxidantspolyphenolspostprandial period |
| spellingShingle | Amanda Cristine de Oliveira Anna Paula Oliveira Gomes Lorena Charife Rodrigues Raisa da Silva Cunha Thaís Martins Serra Raquel Machado Schincaglia Marina Alves Coelho Silva Maria Aderuza Horst Maurício Ariel Rostagno Kelly Grace Magalhães Luiz Carlos Cunha Patrícia Borges Botelho Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial Applied Sciences antioxidants polyphenols postprandial period |
| title | Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial |
| title_full | Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial |
| title_fullStr | Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial |
| title_full_unstemmed | Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial |
| title_short | Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial |
| title_sort | organic beet leaves and stalk juice attenuates the glutathione peroxidase increase induced by high fat meal in dyslipidemic patients a pilot double blind randomized controlled trial |
| topic | antioxidants polyphenols postprandial period |
| url | https://www.mdpi.com/2076-3417/12/4/1973 |
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