Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma
Shaobo Duan,1 Ye Zhang,1 Shuang Xu,1 Pei Jiang,1 Qinghua Qi2 1Department of Health Management, Henan Provincial People’s Hospital Zhengzhou University People’s Hospital, Zhengzhou, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Z...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-08-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/contrast-enhanced-ultrasound-parameters-and-d-dimer-new-prognostic-par-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1811276903563132928 |
|---|---|
| author | Duan S Zhang Y Xu S Jiang P Qi Q |
| author_facet | Duan S Zhang Y Xu S Jiang P Qi Q |
| author_sort | Duan S |
| collection | DOAJ |
| description | Shaobo Duan,1 Ye Zhang,1 Shuang Xu,1 Pei Jiang,1 Qinghua Qi2 1Department of Health Management, Henan Provincial People’s Hospital Zhengzhou University People’s Hospital, Zhengzhou, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Qinghua Qi, Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, Email qiqinghua333@sina.comObjective: To investigate the predictive role of contrast-enhanced ultrasonography (CEUS) plus D-dimer levels in the prognosis of patients with diffuse large B-cell lymphoma (DLBCL).Methods: CEUS was applied to assess lymph nodes in 186 patients with confirmed DLBCL. The clinical data and laboratory indicators were collected from these patients, and a retrospective analysis was conducted on the relationship between the quantitative parameters of CEUS (TTP, PI, AUC, WOT), D-dimer levels, and clinical features of the DLBCL patients. The Cox regression model was used for univariate and multivariate analyses for the risk factors associated with the prognosis.Results: There was an increase of D-dimer levels in advanced DLBCL patients, who were combined with a significant reduction in TTP and WOT and a significant increase in PI and AUC. D-dimer levels and quantitative parameters of CEUS were strongly correlated with the Ann Arbor, B symptoms, International Prognostic Index (IPI), LDH and CRP levels. The results of the Cox regression model indicated that D-dimer levels, TTP and PI, the quantitative parameters of CEUS, were important prognostic factors for DLBCL.Conclusion: CEUS results and D-dimer levels can be used as independent prognostic factors for DLBCL.Keywords: diffuse large B-cell lymphoma, contrast-enhanced ultrasonography, D-dimer, prognosis |
| first_indexed | 2024-04-13T00:06:08Z |
| format | Article |
| id | doaj.art-ba5c4ae5335442fa9b485092b30b8c94 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-13T00:06:08Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-ba5c4ae5335442fa9b485092b30b8c942022-12-22T03:11:14ZengDove Medical PressCancer Management and Research1179-13222022-08-01Volume 142535254477707Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell LymphomaDuan SZhang YXu SJiang PQi QShaobo Duan,1 Ye Zhang,1 Shuang Xu,1 Pei Jiang,1 Qinghua Qi2 1Department of Health Management, Henan Provincial People’s Hospital Zhengzhou University People’s Hospital, Zhengzhou, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Qinghua Qi, Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China, Email qiqinghua333@sina.comObjective: To investigate the predictive role of contrast-enhanced ultrasonography (CEUS) plus D-dimer levels in the prognosis of patients with diffuse large B-cell lymphoma (DLBCL).Methods: CEUS was applied to assess lymph nodes in 186 patients with confirmed DLBCL. The clinical data and laboratory indicators were collected from these patients, and a retrospective analysis was conducted on the relationship between the quantitative parameters of CEUS (TTP, PI, AUC, WOT), D-dimer levels, and clinical features of the DLBCL patients. The Cox regression model was used for univariate and multivariate analyses for the risk factors associated with the prognosis.Results: There was an increase of D-dimer levels in advanced DLBCL patients, who were combined with a significant reduction in TTP and WOT and a significant increase in PI and AUC. D-dimer levels and quantitative parameters of CEUS were strongly correlated with the Ann Arbor, B symptoms, International Prognostic Index (IPI), LDH and CRP levels. The results of the Cox regression model indicated that D-dimer levels, TTP and PI, the quantitative parameters of CEUS, were important prognostic factors for DLBCL.Conclusion: CEUS results and D-dimer levels can be used as independent prognostic factors for DLBCL.Keywords: diffuse large B-cell lymphoma, contrast-enhanced ultrasonography, D-dimer, prognosishttps://www.dovepress.com/contrast-enhanced-ultrasound-parameters-and-d-dimer-new-prognostic-par-peer-reviewed-fulltext-article-CMARdiffuse large b-cell lymphomacontrast-enhanced ultrasonographyd-dimerprognosis |
| spellingShingle | Duan S Zhang Y Xu S Jiang P Qi Q Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma Cancer Management and Research diffuse large b-cell lymphoma contrast-enhanced ultrasonography d-dimer prognosis |
| title | Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma |
| title_full | Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma |
| title_fullStr | Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma |
| title_short | Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma |
| title_sort | contrast enhanced ultrasound parameters and d dimer new prognostic parameters for diffuse large b cell lymphoma |
| topic | diffuse large b-cell lymphoma contrast-enhanced ultrasonography d-dimer prognosis |
| url | https://www.dovepress.com/contrast-enhanced-ultrasound-parameters-and-d-dimer-new-prognostic-par-peer-reviewed-fulltext-article-CMAR |
| work_keys_str_mv | AT duans contrastenhancedultrasoundparametersandddimernewprognosticparametersfordiffuselargebcelllymphoma AT zhangy contrastenhancedultrasoundparametersandddimernewprognosticparametersfordiffuselargebcelllymphoma AT xus contrastenhancedultrasoundparametersandddimernewprognosticparametersfordiffuselargebcelllymphoma AT jiangp contrastenhancedultrasoundparametersandddimernewprognosticparametersfordiffuselargebcelllymphoma AT qiq contrastenhancedultrasoundparametersandddimernewprognosticparametersfordiffuselargebcelllymphoma |