A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer
Leukocytosis is a common feature of malignancies. While controversial, there appears to be an association between the degree of tumor-related leukocytosis and prognosis. In this paper, we provide evidence supporting an untapped clinical paradigm linking G-CSF secretion to the induction of leukocytos...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00295/full |
| _version_ | 1819083539395641344 |
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| author | Montreh Tavakkoli Cy R. Wilkins Jodi V. Mones Michael J. Mauro |
| author_facet | Montreh Tavakkoli Cy R. Wilkins Jodi V. Mones Michael J. Mauro |
| author_sort | Montreh Tavakkoli |
| collection | DOAJ |
| description | Leukocytosis is a common feature of malignancies. While controversial, there appears to be an association between the degree of tumor-related leukocytosis and prognosis. In this paper, we provide evidence supporting an untapped clinical paradigm linking G-CSF secretion to the induction of leukocytosis and expansion of myeloid-derived suppressor cells, providing an explanation for the association between leukocytosis, elevated neutrophil-to-lymphocyte ratios and prognosis in non-small cell lung cancer. Clinically validating this mechanism may identify MDSCs and G-CSF as dynamic markers of early disease progression and therapeutic response, and shed light onto novel therapeutic avenues for the treatment of patients with non-small cell lung cancer. |
| first_indexed | 2024-12-21T20:34:10Z |
| format | Article |
| id | doaj.art-ba5fc6a663c0496ba5de951125cda2da |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T20:34:10Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ba5fc6a663c0496ba5de951125cda2da2022-12-21T18:51:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-04-01910.3389/fonc.2019.00295446375A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung CancerMontreh Tavakkoli0Cy R. Wilkins1Jodi V. Mones2Michael J. Mauro3Department of Internal Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY, United StatesDepartment of Hematology, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Hematology, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Hematology Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesLeukocytosis is a common feature of malignancies. While controversial, there appears to be an association between the degree of tumor-related leukocytosis and prognosis. In this paper, we provide evidence supporting an untapped clinical paradigm linking G-CSF secretion to the induction of leukocytosis and expansion of myeloid-derived suppressor cells, providing an explanation for the association between leukocytosis, elevated neutrophil-to-lymphocyte ratios and prognosis in non-small cell lung cancer. Clinically validating this mechanism may identify MDSCs and G-CSF as dynamic markers of early disease progression and therapeutic response, and shed light onto novel therapeutic avenues for the treatment of patients with non-small cell lung cancer.https://www.frontiersin.org/article/10.3389/fonc.2019.00295/fullgranulocyte-colony stimulating factor (G-CSF)myeloid derived suppressor cell (MDSC)biomarker (development)non-small cell lung cancerleukocytosisparaneoplastic leukocytosis |
| spellingShingle | Montreh Tavakkoli Cy R. Wilkins Jodi V. Mones Michael J. Mauro A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer Frontiers in Oncology granulocyte-colony stimulating factor (G-CSF) myeloid derived suppressor cell (MDSC) biomarker (development) non-small cell lung cancer leukocytosis paraneoplastic leukocytosis |
| title | A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer |
| title_full | A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer |
| title_fullStr | A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer |
| title_full_unstemmed | A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer |
| title_short | A Novel Paradigm Between Leukocytosis, G-CSF Secretion, Neutrophil-to-Lymphocyte Ratio, Myeloid-Derived Suppressor Cells, and Prognosis in Non-small Cell Lung Cancer |
| title_sort | novel paradigm between leukocytosis g csf secretion neutrophil to lymphocyte ratio myeloid derived suppressor cells and prognosis in non small cell lung cancer |
| topic | granulocyte-colony stimulating factor (G-CSF) myeloid derived suppressor cell (MDSC) biomarker (development) non-small cell lung cancer leukocytosis paraneoplastic leukocytosis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00295/full |
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