Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction

A concise and efficient approach to synthesizing coumarin-fused pyrazolo[3,4-<i>b</i>]pyridine via silica sulfuric acid (SSA) catalyzed three-component domino reaction under microwave irradiation has been demonstrated. Participation of various alcohols in construction of coumarin derivat...

Full description

Bibliographic Details
Main Authors:	Wei Lin, Cangwei Zhuang, Xiuxiu Hu, Juanjuan Zhang, Juxian Wang
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Molecules
Subjects:	coumarin pyrazolo[3,4-<i>b</i>]pyridine synthesis silica sulfuric acid
Online Access:	https://www.mdpi.com/1420-3049/24/15/2835

Similar Items

Synthesis of Novel Pyrazolo[3,4-<i>b</i>]pyridines with Affinity for β-Amyloid Plaques
by: Veroniki P. Vidali, et al.
Published: (2022-02-01)

1<i>H</i>-Pyrazolo[3,4-<i>b</i>]pyridines: Synthesis and Biomedical Applications
by: Ana Donaire-Arias, et al.
Published: (2022-03-01)

Pyrazolo[3,4-b]pyridin-3(2H)-one derivatives: Synthesis and their investigation of mosquito larvicidal activity
by: Mohammed Al-Zharani, et al.
Published: (2022-02-01)

Synthesis of Diversified Pyrazolo[3,4-<i>b</i>]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches
by: Xiao-Yu Miao, et al.
Published: (2022-09-01)

Synthesis of a New Series of Pyridine and Fused Pyridine Derivatives
by: Siham AbdulRahman Al-Issa
Published: (2012-09-01)

5-(Indol-2-yl)pyrazolo[3,4-<i>b</i>]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
by: David Ramírez, et al.
Published: (2021-06-01)

5-Methyl-1-phenyl-3-(thieno[2,3-<i>d</i>]pyrimidin-4-yl)chromeno[4,3-<i>d</i>]pyrazolo[3,4-<i>b</i>]pyridin-6(3<i>H</i>)-one
by: Xuelian Yin, et al.
Published: (2022-10-01)

3,4,6-Trimethyl-1-phenyl-5-(thiophen-3-yl)-1H-pyrazolo[3,4-b]pyridine
by: Mohamed Loubidi, et al.
Published: (2018-11-01)

Synthesis and In Vitro Anticancer Activity of Novel 4-Aryl-3-(4-methoxyphenyl)-1-phenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines Arrest Cell Cycle and Induce Cell Apoptosis by Inhibiting CDK2 and/or CDK9
by: Basma S. Almansour, et al.
Published: (2023-09-01)

New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity
by: RAQUEL R.S. SALVADOR, et al.

<i>N′</i>-Acetyl-3-methyl-1,6-diphenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-4-carbohydrazide
by: Júlio C. A. V. Soares, et al.
Published: (2020-01-01)

Molecular Hybrids of Pyazolo[3,4-<i>b</i>]pyridine and Triazole: Design, Synthesis and In Vitro Antibacterial Studies
by: Narasimha Rao Bandaru, et al.
Published: (2022-11-01)

Ethyl 4,6-dimethyl-3-oxo-2-phenyl-3,7-dihydro-2H-pyrazolo[3,4-b]pyridine-5-carboxylate monohydrate
by: Soufiane Akhramez, et al.
Published: (2016-10-01)

Crystal structure analysis of ethyl 6-(4-methoxyphenyl)-1-methyl-4-methylsulfanyl-3-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
by: H. Surya Prakash Rao, et al.
Published: (2020-08-01)

Straightforward and Efficient Protocol for the Synthesis of Pyrazolo [4,3-<i>b</i>]pyridines and Indazoles
by: Vladislav V. Nikol’skiy, et al.
Published: (2023-01-01)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-<i>d</i>]pyrimidines Kinase Inhibitors
by: Chiara Greco, et al.
Published: (2020-11-01)

Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo[3,4-b]pyridin-6(7H)-one Derivatives
by: Deming Wang, et al.
Published: (2013-10-01)

Identification and Biological Characterization of the Pyrazolo[3,4-<i>d</i>]pyrimidine Derivative SI388 Active as Src Inhibitor
by: Claudia Contadini, et al.
Published: (2023-07-01)

Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors
by: Anna-Maria Fantel, et al.
Published: (2020-08-01)

Crystal structure of [4-(2-methoxyphenyl)-3-methyl-1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-b]pyridin-5-yl](thiophen-2-yl)methanone
by: V. Rajni Swamy, et al.
Published: (2014-09-01)

New one-pot synthesis of 4-arylpyrazolo[3,4-b]pyridin-6-ones based on 5-aminopyrazoles and azlactones
by: Vladislav Yu. Shuvalov, et al.
Published: (2023-08-01)

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity
by: Adel A.-H. Abdel-Rahman, et al.
Published: (2021-06-01)

6-(Chloromethyl)-<i>N</i>,1-dimethyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-amine
by: Vladimir A. Ogurtsov, et al.
Published: (2021-11-01)

A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines
by: Mingxing Liu, et al.
Published: (2015-11-01)

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
by: Yin Sun, et al.
Published: (2022-12-01)

4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine
by: Eun Sun Noh, et al.
Published: (2020-05-01)

Design, Synthesis and Biological Evaluation of Novel Pleuromutilin Derivatives Containing 6-Chloro-1-R-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine-4-amino Side Chain
by: Jun Wang, et al.
Published: (2023-05-01)

Poly[[tetramethanolbis[4-oxo-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-olato]disodium]–diethyl ether–methanol (1/1/2)]
by: Bassam Abu Thaher, et al.
Published: (2016-07-01)

4-Chloro-6-(chloromethyl)-1-methyl-1<em>H</em>-pyrazolo[3,4-<em>d</em>]pyrimidine
by: Vladimir A. Ogurtsov, et al.
Published: (2021-07-01)

1<i>H</i>-Pyrazolo[3,4-<i>b</i>]quinolines: Synthesis and Properties over 100 Years of Research
by: Andrzej Danel, et al.
Published: (2022-04-01)

(<i>E</i>)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2<i>H</i>-pyrazolo[4,3<i>c</i>] Pyridine
by: Enda Mora, et al.
Published: (2021-07-01)

New approach toward the synthesis of deuterated pyrazolo[1,5-a]pyridines and 1,2,4-triazolo[1,5-a]pyridines
by: Aleksey Yu. Vorob’ev, et al.
Published: (2017-05-01)

Design, Synthesis, In Vitro, and In Silico Studies of New <i>N</i><sup>5</sup>-Substituted-pyrazolo[3,4-<i>d</i>]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors
by: Waheed A. Zaki, et al.
Published: (2023-11-01)

Novel Glu-based pyrazolo[3,4-d]pyrimidine analogues: design, synthesis and biological evaluation as DHFR and TS dual inhibitors
by: Mater Mahnashi, et al.
Published: (2023-12-01)

Synthesis of some pyrazolo[3,4-d]pyrimidines and their fused triazole and tetrazole derivatives
by: Swelam Samira A., et al.
Published: (1999-01-01)

Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents
by: Nasser S.M. Ismail, et al.
Published: (2016-06-01)

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-<i>d</i>]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
by: Federica Poggialini, et al.
Published: (2023-01-01)

Synthesis and Anticancer Activity of Some New Pyrazolo[3,4-d]pyrimidin-4-one Derivatives
by: Khaled R. A. Abdellatif, et al.
Published: (2014-03-01)

(3,5-Dimethylpyrazol-1-yl)-[4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl]methanone
by: Rania B. Bakr, et al.
Published: (2016-11-01)

Theoretical and experimental investigations on the structure and vibrational spectra of 6-amino-3-methyl-1-phenyl-1H-pyrazolo-[3,4-b]pyridine-5-carboxylic acid and 6,7-dihydro-3-methyl-6-oxo-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
by: KHALED BAHGAT, et al.
Published: (2009-05-01)